======= PRPF18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRPF18
  * **<color #00a2e8>Official Name</color>**: pre-mRNA processing factor 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8559|8559]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99633|Q99633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRPF18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRPF18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604993|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the second step of pre-mRNA splicing. {ECO:0000269|PubMed:9000057}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRP4|
|Prp18|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type post-spliceosomal complex|
|nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|
|generation of catalytic spliceosome for second transesterification step|
|nuclear retention of unspliced pre-mRNA at the site of transcription|
|second spliceosomal transesterification activity|
|nuclear retention of pre-mRNA at the site of transcription|
|spliceosomal conformational changes to generate catalytic conformation|
|intracellular mRNA localization|
|nuclear RNA surveillance|
|nuclear mRNA surveillance|
|RNA surveillance|
|U5 snRNP|
|U4/U6 x U5 tri-snRNP complex|
|spliceosomal complex|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA localization|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|nuclear speck|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|protein-containing complex assembly|
|cellular macromolecule localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.3|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.27|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.96|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.8|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.76|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.74|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.71|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.7|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.72|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.73|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.76|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.77|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.77|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.8|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.04|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.22|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.66|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.69|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.73|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|3.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1569
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRPF18 Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>