======= PRPF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRPF3
  * **<color #00a2e8>Official Name</color>**: pre-mRNA processing factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9129|9129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43395|O43395]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRPF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRPF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607301|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. {ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889, ECO:0000303|PubMed:20595234}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRP3|
|DUF1115|
|PWI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spliceosomal tri-snRNP complex assembly|
|U4/U6 x U5 tri-snRNP complex|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|Cajal body|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|identical protein binding|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.75|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.74|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.79|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.83|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.83|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.84|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox7a2l|COX7A2L]]|0.502|
|[[:human genes:r:rrm1|RRM1]]|0.468|
|[[:human genes:c:cnot3|CNOT3]]|0.462|
|[[:human genes:n:narfl|NARFL]]|0.454|
|[[:human genes:p:polr2j3|POLR2J3]]|0.451|
|[[:human genes:r:rps2|RPS2]]|0.451|
|[[:human genes:a:ahctf1|AHCTF1]]|0.442|
|[[:human genes:p:psmb2|PSMB2]]|0.437|
|[[:human genes:c:cdc73|CDC73]]|0.43|
|[[:human genes:d:dtl|DTL]]|0.425|
|[[:human genes:s:smndc1|SMNDC1]]|0.425|
|[[:human genes:u:utp3|UTP3]]|0.423|
|[[:human genes:r:rpl35|RPL35]]|0.421|
|[[:human genes:c:cln6|CLN6]]|0.42|
|[[:human genes:n:nelfcd|NELFCD]]|0.417|
|[[:human genes:r:rps7|RPS7]]|0.412|
|[[:human genes:p:psmb1|PSMB1]]|0.41|
|[[:human genes:x:xylt2|XYLT2]]|0.408|
|[[:human genes:t:taf1|TAF1]]|0.407|
|[[:human genes:c:ckap5|CKAP5]]|0.407|
|[[:human genes:p:pds5b|PDS5B]]|0.407|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.404|
|[[:human genes:m:mrs2|MRS2]]|0.404|
|[[:human genes:d:ddx3x|DDX3X]]|0.402|
|[[:human genes:t:tinf2|TINF2]]|0.402|
|[[:human genes:p:plekha4|PLEKHA4]]|0.402|
|[[:human genes:r:rps12|RPS12]]|0.401|
|[[:human genes:t:tceb3c|TCEB3C]]|0.401|
|[[:human genes:a:akirin2|AKIRIN2]]|0.401|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 377/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|21/28|
|bone|9/26|
|breast|15/33|
|central nervous system|20/56|
|cervix|1/4|
|colorectal|9/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|9/21|
|liver|10/20|
|lung|39/75|
|lymphocyte|11/16|
|ovary|14/26|
|pancreas|16/24|
|peripheral nervous system|9/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|12/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRPF3 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>