======= PRRX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRRX1
  * **<color #00a2e8>Official Name</color>**: paired related homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5396|5396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54821|P54821]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRRX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRRX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|OAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuron fate determination|
|HMG box domain binding|
|middle ear morphogenesis|
|neuronal stem cell population maintenance|
|positive regulation of mesenchymal cell proliferation|
|regulation of neuron projection regeneration|
|positive regulation of smoothened signaling pathway|
|regulation of mesenchymal cell proliferation|
|cell fate determination|
|embryonic cranial skeleton morphogenesis|
|artery morphogenesis|
|neuron fate commitment|
|cranial skeletal system development|
|regulation of smoothened signaling pathway|
|artery development|
|roof of mouth development|
|embryonic skeletal system morphogenesis|
|inner ear morphogenesis|
|ear morphogenesis|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|stem cell population maintenance|
|maintenance of cell number|
|limb morphogenesis|
|appendage morphogenesis|
|cartilage development|
|appendage development|
|limb development|
|inner ear development|
|ear development|
|connective tissue development|
|skeletal system morphogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|sensory organ morphogenesis|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|blood vessel morphogenesis|
|embryonic organ development|
|blood vessel development|
|skeletal system development|
|regulation of neuron projection development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|sensory organ development|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|regulation of neurogenesis|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|embryo development|
|neuron differentiation|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.78|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.73|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9882
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRRX1 Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>