======= PSAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSAP
  * **<color #00a2e8>Official Name</color>**: prosaposin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5660|5660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07602|P07602]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176801|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SapA|
|SapB 2|
|SapB 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ganglioside GM1 transport to membrane|
|ganglioside GM2 binding|
|ganglioside GM3 binding|
|ganglioside GP1c binding|
|ganglioside GM1 binding|
|galactosylceramide catabolic process|
|ganglioside GT1b binding|
|corneocyte development|
|galactolipid catabolic process|
|cornified envelope assembly|
|beta-galactosidase activity|
|glycolipid transport|
|glycosylceramide catabolic process|
|micturition|
|galactosylceramide metabolic process|
|prostate gland growth|
|galactolipid metabolic process|
|epithelial cell differentiation involved in prostate gland development|
|keratinocyte development|
|glycosphingolipid catabolic process|
|ceramide transport|
|glycolipid catabolic process|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|glycosylceramide metabolic process|
|ceramide catabolic process|
|negative regulation of cellular response to drug|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to drug|
|walking behavior|
|sphingolipid catabolic process|
|regulation of response to reactive oxygen species|
|membrane assembly|
|membrane lipid catabolic process|
|regulation of cellular response to drug|
|membrane biogenesis|
|excretion|
|prostate gland development|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|enzyme activator activity|
|negative regulation of response to oxidative stress|
|cochlea development|
|neuromuscular process controlling balance|
|azurophil granule membrane|
|regulation of oxidative stress-induced cell death|
|glycosphingolipid metabolic process|
|G protein-coupled receptor binding|
|carbohydrate derivative transport|
|regulation of cellular response to oxidative stress|
|ceramide metabolic process|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of response to oxidative stress|
|plasma membrane organization|
|lysosomal lumen|
|organ growth|
|regulation of response to drug|
|protease binding|
|phospholipid binding|
|lysosomal transport|
|myelination|
|axon ensheathment|
|neuromuscular process|
|ensheathment of neurons|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|renal system process|
|late endosome|
|platelet degranulation|
|vacuolar transport|
|sensory perception of sound|
|sphingolipid metabolic process|
|lipid binding|
|sensory perception of mechanical stimulus|
|carbohydrate derivative catabolic process|
|epithelial cell development|
|inner ear development|
|locomotory behavior|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|ear development|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|lysosome|
|keratinocyte differentiation|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|lysosomal membrane|
|epidermal cell differentiation|
|urogenital system development|
|lipid localization|
|regulation of autophagy|
|collagen-containing extracellular matrix|
|skin development|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|gland development|
|epidermis development|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|organic anion transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of MAPK cascade|
|sensory organ development|
|behavior|
|anion transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|cellular amide metabolic process|
|exocytosis|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|leukocyte activation|
|cellular lipid metabolic process|
|sensory perception|
|regulation of catabolic process|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|epithelium development|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.25|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.14|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.02|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.98|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.76|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.78|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.84|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.84|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.89|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.98|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|3.95|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|4.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf93|C14orf93]]|0.537|
|[[:human genes:p:polr2j3|POLR2J3]]|0.526|
|[[:human genes:v:vasn|VASN]]|0.495|
|[[:human genes:p:psmb4|PSMB4]]|0.491|
|[[:human genes:s:snrnp70|SNRNP70]]|0.488|
|[[:human genes:p:psmc6|PSMC6]]|0.477|
|[[:human genes:s:s1pr4|S1PR4]]|0.477|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.474|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.473|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.468|
|[[:human genes:e:egr2|EGR2]]|0.467|
|[[:human genes:a:aqr|AQR]]|0.467|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.465|
|[[:human genes:r:rps2|RPS2]]|0.464|
|[[:human genes:r:rps7|RPS7]]|0.463|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.462|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.462|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.461|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.461|
|[[:human genes:p:psmb1|PSMB1]]|0.454|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.453|
|[[:human genes:n:npipb5|NPIPB5]]|0.451|
|[[:human genes:s:slc38a7|SLC38A7]]|0.448|
|[[:human genes:r:rbm39|RBM39]]|0.447|
|[[:human genes:s:supt6h|SUPT6H]]|0.445|
|[[:human genes:o:orc1|ORC1]]|0.445|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.443|
|[[:human genes:r:rrn3|RRN3]]|0.441|
|[[:human genes:i:iscu|ISCU]]|0.44|
|[[:human genes:s:ssh2|SSH2]]|0.438|
|[[:human genes:z:znf106|ZNF106]]|0.438|
|[[:human genes:c:cwc22|CWC22]]|0.438|
|[[:human genes:p:pola2|POLA2]]|0.437|
|[[:human genes:c:ckap5|CKAP5]]|0.435|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.434|
|[[:human genes:p:psmb2|PSMB2]]|0.434|
|[[:human genes:m:med12|MED12]]|0.433|
|[[:human genes:p:psma6|PSMA6]]|0.432|
|[[:human genes:c:cdc73|CDC73]]|0.429|
|[[:human genes:c:chd4|CHD4]]|0.429|
|[[:human genes:c:cbwd3|CBWD3]]|0.427|
|[[:human genes:p:pola1|POLA1]]|0.426|
|[[:human genes:c:cope|COPE]]|0.425|
|[[:human genes:t:taf15|TAF15]]|0.424|
|[[:human genes:l:lipe|LIPE]]|0.424|
|[[:human genes:t:ticrr|TICRR]]|0.423|
|[[:human genes:r:rbbp5|RBBP5]]|0.422|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.422|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.422|
|[[:human genes:t:trim52|TRIM52]]|0.417|
|[[:human genes:m:mt1e|MT1E]]|0.416|
|[[:human genes:o:orc6|ORC6]]|0.416|
|[[:human genes:t:tceb3c|TCEB3C]]|0.415|
|[[:human genes:n:napa|NAPA]]|0.415|
|[[:human genes:t:tuba8|TUBA8]]|0.414|
|[[:human genes:c:cbwd5|CBWD5]]|0.414|
|[[:human genes:t:tfip11|TFIP11]]|0.413|
|[[:human genes:u:upf1|UPF1]]|0.413|
|[[:human genes:w:wdr75|WDR75]]|0.412|
|[[:human genes:t:tpx2|TPX2]]|0.41|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.409|
|[[:human genes:t:traip|TRAIP]]|0.409|
|[[:human genes:f:fancm|FANCM]]|0.408|
|[[:human genes:n:nfatc4|NFATC4]]|0.408|
|[[:human genes:r:rrp7a|RRP7A]]|0.406|
|[[:human genes:s:syt9|SYT9]]|0.406|
|[[:human genes:f:fam86b2|FAM86B2]]|0.405|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.404|
|[[:human genes:a:akirin2|AKIRIN2]]|0.403|
|[[:human genes:p:paf1|PAF1]]|0.403|
|[[:human genes:r:rpl35|RPL35]]|0.402|
|[[:human genes:r:rps14|RPS14]]|0.401|
|[[:human genes:f:fam160a1|FAM160A1]]|0.401|
|[[:human genes:s:sec13|SEC13]]|0.4|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.4|
|[[:human genes:r:riok2|RIOK2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1948
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSAP Expression in NALM6 Cells: 8.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>