======= PSMA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMA3
  * **<color #00a2e8>Official Name</color>**: proteasome 20S subunit alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5684|5684]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25788|P25788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Proteasome|
|Proteasome A N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome core complex, alpha-subunit complex|
|threonine-type endopeptidase activity|
|proteasome core complex|
|proteasomal ubiquitin-independent protein catabolic process|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|endopeptidase activity|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cellular amine metabolic process|
|NIK/NF-kappaB signaling|
|anaphase-promoting complex-dependent catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|antigen processing and presentation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|regulation of animal organ morphogenesis|
|activation of innate immune response|
|response to tumor necrosis factor|
|synapse|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|response to oxygen levels|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|regulation of mitotic cell cycle|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulation of proteolysis|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-3.12|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.77|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.73|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.65|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.63|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.41|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.36|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.29|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.04|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.02|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.97|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.94|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.94|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.88|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.76|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.73|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.71|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.7|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.7|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.7|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.74|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.98|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.06|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.09|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.11|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.18|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.25|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.31|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma6|PSMA6]]|0.443|
|[[:human genes:a:akap1|AKAP1]]|0.435|
|[[:human genes:z:znf830|ZNF830]]|0.434|
|[[:human genes:p:psma1|PSMA1]]|0.431|
|[[:human genes:p:psma2|PSMA2]]|0.425|
|[[:human genes:c:col2a1|COL2A1]]|0.421|
|[[:human genes:a:aatf|AATF]]|0.42|
|[[:human genes:p:psmb4|PSMB4]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1607
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMA3 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>