======= PSMA7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMA7
  * **<color #00a2e8>Official Name</color>**: proteasome 20S subunit alpha 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5688|5688]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14818|O14818]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMA7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMA7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606607|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF- 1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Proteasome|
|Proteasome A N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome core complex, alpha-subunit complex|
|threonine-type endopeptidase activity|
|proteasome core complex|
|proteasomal ubiquitin-independent protein catabolic process|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|endopeptidase activity|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|NIK/NF-kappaB signaling|
|regulation of cellular amine metabolic process|
|anaphase-promoting complex-dependent catabolic process|
|postsynapse|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|negative regulation of canonical Wnt signaling pathway|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|antigen processing and presentation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|regulation of animal organ morphogenesis|
|activation of innate immune response|
|response to tumor necrosis factor|
|protein deubiquitination|
|regulation of canonical Wnt signaling pathway|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|response to oxygen levels|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|regulation of mitotic cell cycle|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-3.19|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.64|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.64|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.64|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.4|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.23|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.2|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.14|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.09|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.09|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.08|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.99|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.95|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.94|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.91|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.85|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.83|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.81|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.79|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.77|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.74|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.73|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.72|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.71|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.74|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.79|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.8|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.82|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.85|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.86|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.87|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.91|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.03|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.18|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.21|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.34|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.52|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.614|
|[[:human genes:p:psmb4|PSMB4]]|0.586|
|[[:human genes:p:psma6|PSMA6]]|0.572|
|[[:human genes:d:ddx56|DDX56]]|0.554|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.536|
|[[:human genes:p:psmd2|PSMD2]]|0.535|
|[[:human genes:k:kctd17|KCTD17]]|0.535|
|[[:human genes:i:ints5|INTS5]]|0.533|
|[[:human genes:t:tceb3c|TCEB3C]]|0.532|
|[[:human genes:r:rpl35|RPL35]]|0.522|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.52|
|[[:human genes:p:psmb1|PSMB1]]|0.519|
|[[:human genes:c:chd4|CHD4]]|0.519|
|[[:human genes:d:ddtl|DDTL]]|0.518|
|[[:human genes:p:psmb2|PSMB2]]|0.515|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.514|
|[[:human genes:c:cbwd6|CBWD6]]|0.514|
|[[:human genes:n:nip7|NIP7]]|0.513|
|[[:human genes:c:cdc73|CDC73]]|0.512|
|[[:human genes:m:mt1e|MT1E]]|0.51|
|[[:human genes:c:cbwd3|CBWD3]]|0.51|
|[[:human genes:c:ccna2|CCNA2]]|0.51|
|[[:human genes:p:psmd1|PSMD1]]|0.505|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.504|
|[[:human genes:p:pole|POLE]]|0.501|
|[[:human genes:c:cbwd5|CBWD5]]|0.499|
|[[:human genes:l:lrr1|LRR1]]|0.497|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.494|
|[[:human genes:r:rps12|RPS12]]|0.494|
|[[:human genes:r:rps9|RPS9]]|0.494|
|[[:human genes:n:nup133|NUP133]]|0.486|
|[[:human genes:m:myh7b|MYH7B]]|0.485|
|[[:human genes:c:ccdc116|CCDC116]]|0.485|
|[[:human genes:r:rps2|RPS2]]|0.483|
|[[:human genes:a:atp13a1|ATP13A1]]|0.481|
|[[:human genes:p:ppm1d|PPM1D]]|0.48|
|[[:human genes:s:slc6a17|SLC6A17]]|0.474|
|[[:human genes:r:rpl18|RPL18]]|0.474|
|[[:human genes:t:taf1|TAF1]]|0.474|
|[[:human genes:p:psmd11|PSMD11]]|0.474|
|[[:human genes:n:npipb5|NPIPB5]]|0.474|
|[[:human genes:n:narfl|NARFL]]|0.474|
|[[:human genes:n:nup160|NUP160]]|0.473|
|[[:human genes:r:rfc1|RFC1]]|0.473|
|[[:human genes:e:exosc9|EXOSC9]]|0.472|
|[[:human genes:b:bysl|BYSL]]|0.471|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.471|
|[[:human genes:n:ncapg|NCAPG]]|0.47|
|[[:human genes:p:psmc1|PSMC1]]|0.469|
|[[:human genes:b:brix1|BRIX1]]|0.468|
|[[:human genes:m:myb|MYB]]|0.467|
|[[:human genes:n:nop16|NOP16]]|0.467|
|[[:human genes:z:zfand5|ZFAND5]]|0.465|
|[[:human genes:t:twistnb|TWISTNB]]|0.464|
|[[:human genes:p:polr2f|POLR2F]]|0.463|
|[[:human genes:n:nupl1|NUPL1]]|0.463|
|[[:human genes:b:brd2|BRD2]]|0.463|
|[[:human genes:t:tspy2|TSPY2]]|0.462|
|[[:human genes:e:exosc5|EXOSC5]]|0.462|
|[[:human genes:r:rpl6|RPL6]]|0.461|
|[[:human genes:c:copg1|COPG1]]|0.461|
|[[:human genes:s:smg7|SMG7]]|0.459|
|[[:human genes:c:copb1|COPB1]]|0.459|
|[[:human genes:c:cgb2|CGB2]]|0.457|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.456|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.456|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.455|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.455|
|[[:human genes:p:pds5b|PDS5B]]|0.455|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.455|
|[[:human genes:v:vps28|VPS28]]|0.454|
|[[:human genes:r:rps3a|RPS3A]]|0.453|
|[[:human genes:s:supt5h|SUPT5H]]|0.453|
|[[:human genes:p:polr2l|POLR2L]]|0.452|
|[[:human genes:s:scaf1|SCAF1]]|0.451|
|[[:human genes:d:dhx38|DHX38]]|0.45|
|[[:human genes:i:igfn1|IGFN1]]|0.45|
|[[:human genes:r:rrn3|RRN3]]|0.45|
|[[:human genes:s:s1pr4|S1PR4]]|0.449|
|[[:human genes:p:pola1|POLA1]]|0.449|
|[[:human genes:p:psmc6|PSMC6]]|0.448|
|[[:human genes:d:dtl|DTL]]|0.448|
|[[:human genes:m:mylk3|MYLK3]]|0.448|
|[[:human genes:c:cdc45|CDC45]]|0.447|
|[[:human genes:p:polr2d|POLR2D]]|0.446|
|[[:human genes:r:rps5|RPS5]]|0.445|
|[[:human genes:t:traip|TRAIP]]|0.445|
|[[:human genes:m:madcam1|MADCAM1]]|0.444|
|[[:human genes:r:rps28|RPS28]]|0.441|
|[[:human genes:c:col2a1|COL2A1]]|0.44|
|[[:human genes:n:nol10|NOL10]]|0.44|
|[[:human genes:r:rad51|RAD51]]|0.439|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.439|
|[[:human genes:x:xab2|XAB2]]|0.437|
|[[:human genes:u:upf1|UPF1]]|0.437|
|[[:human genes:p:psmd14|PSMD14]]|0.437|
|[[:human genes:n:npipb8|NPIPB8]]|0.436|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.436|
|[[:human genes:n:nfatc4|NFATC4]]|0.435|
|[[:human genes:u:utp20|UTP20]]|0.435|
|[[:human genes:a:acbd4|ACBD4]]|0.435|
|[[:human genes:t:tspy1|TSPY1]]|0.434|
|[[:human genes:r:rps7|RPS7]]|0.434|
|[[:human genes:c:cdc6|CDC6]]|0.433|
|[[:human genes:r:rpl14|RPL14]]|0.433|
|[[:human genes:r:rpl8|RPL8]]|0.432|
|[[:human genes:c:ckap5|CKAP5]]|0.432|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.432|
|[[:human genes:p:polr1a|POLR1A]]|0.431|
|[[:human genes:v:vasn|VASN]]|0.431|
|[[:human genes:e:eif4a3|EIF4A3]]|0.43|
|[[:human genes:c:cactin|CACTIN]]|0.43|
|[[:human genes:r:rrp15|RRP15]]|0.43|
|[[:human genes:a:aamp|AAMP]]|0.43|
|[[:human genes:s:snrpa1|SNRPA1]]|0.428|
|[[:human genes:p:pola2|POLA2]]|0.428|
|[[:human genes:n:nup54|NUP54]]|0.428|
|[[:human genes:c:chaf1a|CHAF1A]]|0.427|
|[[:human genes:a:ankle2|ANKLE2]]|0.427|
|[[:human genes:z:znf830|ZNF830]]|0.427|
|[[:human genes:s:sf3a3|SF3A3]]|0.426|
|[[:human genes:a:ahctf1|AHCTF1]]|0.424|
|[[:human genes:c:cep192|CEP192]]|0.423|
|[[:human genes:r:rundc3a|RUNDC3A]]|0.422|
|[[:human genes:g:gid4|GID4]]|0.422|
|[[:human genes:c:casc5|CASC5]]|0.421|
|[[:human genes:r:rrp7a|RRP7A]]|0.421|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.42|
|[[:human genes:r:rps11|RPS11]]|0.42|
|[[:human genes:d:ddx21|DDX21]]|0.42|
|[[:human genes:l:lad1|LAD1]]|0.42|
|[[:human genes:r:rpl9|RPL9]]|0.419|
|[[:human genes:f:fam20a|FAM20A]]|0.419|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.419|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.419|
|[[:human genes:p:psmc2|PSMC2]]|0.418|
|[[:human genes:a:aatf|AATF]]|0.417|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.417|
|[[:human genes:f:fcn2|FCN2]]|0.417|
|[[:human genes:d:dnm2|DNM2]]|0.415|
|[[:human genes:r:rnpc3|RNPC3]]|0.415|
|[[:human genes:c:cgb1|CGB1]]|0.414|
|[[:human genes:r:rpl30|RPL30]]|0.414|
|[[:human genes:r:rrp1|RRP1]]|0.414|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:d:ddt|DDT]]|0.413|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.413|
|[[:human genes:u:utp3|UTP3]]|0.412|
|[[:human genes:r:rpsa|RPSA]]|0.412|
|[[:human genes:c:ctage4|CTAGE4]]|0.411|
|[[:human genes:c:chmp2a|CHMP2A]]|0.411|
|[[:human genes:o:orc1|ORC1]]|0.411|
|[[:human genes:t:tsr1|TSR1]]|0.41|
|[[:human genes:s:ssh2|SSH2]]|0.41|
|[[:human genes:p:plk1|PLK1]]|0.41|
|[[:human genes:s:supt6h|SUPT6H]]|0.41|
|[[:human genes:s:slc38a7|SLC38A7]]|0.409|
|[[:human genes:h:hivep3|HIVEP3]]|0.409|
|[[:human genes:h:hap1|HAP1]]|0.408|
|[[:human genes:s:sap30bp|SAP30BP]]|0.408|
|[[:human genes:n:nup98|NUP98]]|0.407|
|[[:human genes:f:fam86b2|FAM86B2]]|0.407|
|[[:human genes:w:wdr75|WDR75]]|0.407|
|[[:human genes:s:sf3a1|SF3A1]]|0.407|
|[[:human genes:c:c14orf93|C14orf93]]|0.405|
|[[:human genes:c:ctage9|CTAGE9]]|0.405|
|[[:human genes:r:rbm39|RBM39]]|0.405|
|[[:human genes:d:dock6|DOCK6]]|0.405|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.404|
|[[:human genes:z:zmat5|ZMAT5]]|0.403|
|[[:human genes:a:adrm1|ADRM1]]|0.403|
|[[:human genes:a:acsf2|ACSF2]]|0.403|
|[[:human genes:f:fam25b|FAM25B]]|0.402|
|[[:human genes:g:golga8o|GOLGA8O]]|0.402|
|[[:human genes:r:rpl34|RPL34]]|0.402|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.401|
|[[:human genes:t:tram1|TRAM1]]|0.401|
|[[:human genes:d:dido1|DIDO1]]|0.4|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMA7 Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>