======= PSMB5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMB5
  * **<color #00a2e8>Official Name</color>**: proteasome 20S subunit beta 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5693|5693]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28074|P28074]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMB5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMB5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Proteasome|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome core complex, beta-subunit complex|
|threonine-type endopeptidase activity|
|proteasome core complex|
|proteasomal ubiquitin-independent protein catabolic process|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|endopeptidase activity|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cellular amine metabolic process|
|NIK/NF-kappaB signaling|
|anaphase-promoting complex-dependent catabolic process|
|peptidase activity|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|antigen processing and presentation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|regulation of animal organ morphogenesis|
|activation of innate immune response|
|response to tumor necrosis factor|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|response to oxygen levels|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|centrosome|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|activation of immune response|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-6.46|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-3.58|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.06|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.79|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.78|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb8|PSMB8]]|0.496|
|[[:human genes:p:psmb6|PSMB6]]|0.457|
|[[:human genes:k:kiaa0368|KIAA0368]]|0.449|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 665/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|17/28|
|bone|26/26|
|breast|31/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|14/21|
|liver|19/20|
|lung|71/75|
|lymphocyte|8/16|
|ovary|25/26|
|pancreas|21/24|
|peripheral nervous system|16/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMB5 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>