======= PSMC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMC3
  * **<color #00a2e8>Official Name</color>**: proteasome 26S subunit, ATPase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5702|5702]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17980|P17980]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186852|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by host of viral transcription|
|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|negative regulation by host of viral process|
|proteasome regulatory particle, base subcomplex|
|regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|negative regulation by host of viral transcription|
|proteasome accessory complex|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|negative regulation of viral transcription|
|positive regulation of DNA-templated transcription, initiation|
|regulation of transcription initiation from RNA polymerase II promoter|
|modulation by host of viral process|
|regulation of DNA-templated transcription, initiation|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of viral transcription|
|modification by host of symbiont morphology or physiology|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|interaction with symbiont|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cellular amine metabolic process|
|NIK/NF-kappaB signaling|
|anaphase-promoting complex-dependent catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|P-body|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|blastocyst development|
|negative regulation of viral process|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|secretory granule lumen|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|ficolin-1-rich granule lumen|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|modification of morphology or physiology of other organism|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|positive regulation of Wnt signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|regulation of viral process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of multi-organism process|
|cellular response to oxygen levels|
|antigen processing and presentation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|ATPase activity|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|activation of innate immune response|
|regulation of animal organ morphogenesis|
|response to tumor necrosis factor|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|MAPK cascade|
|in utero embryonic development|
|response to oxygen levels|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|activation of immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulated exocytosis|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|leukocyte activation|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|embryo development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.26|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.24|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.15|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.1|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.77|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.75|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.74|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.7|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.76|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.77|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.78|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.78|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.8|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.81|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.83|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.84|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.85|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.88|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.88|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.89|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.89|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.93|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.93|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.93|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.95|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.98|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.02|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.03|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.04|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.04|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.05|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.07|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.14|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.19|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.19|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.24|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.28|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.3|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.35|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.65|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.66|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.7|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pan3|PAN3]]|0.511|
|[[:human genes:d:dtl|DTL]]|0.474|
|[[:human genes:p:psmd1|PSMD1]]|0.464|
|[[:human genes:v:vasn|VASN]]|0.459|
|[[:human genes:l:lrr1|LRR1]]|0.452|
|[[:human genes:p:psmc1|PSMC1]]|0.449|
|[[:human genes:p:psmb4|PSMB4]]|0.448|
|[[:human genes:p:psmd11|PSMD11]]|0.448|
|[[:human genes:z:zfand5|ZFAND5]]|0.443|
|[[:human genes:c:cope|COPE]]|0.437|
|[[:human genes:u:upf1|UPF1]]|0.425|
|[[:human genes:c:chd4|CHD4]]|0.425|
|[[:human genes:d:dnm2|DNM2]]|0.419|
|[[:human genes:e:exosc9|EXOSC9]]|0.418|
|[[:human genes:r:rpsa|RPSA]]|0.416|
|[[:human genes:s:smg7|SMG7]]|0.415|
|[[:human genes:r:ranbp2|RANBP2]]|0.415|
|[[:human genes:k:kpnb1|KPNB1]]|0.414|
|[[:human genes:t:tagln|TAGLN]]|0.413|
|[[:human genes:c:ccna2|CCNA2]]|0.41|
|[[:human genes:g:golga8j|GOLGA8J]]|0.406|
|[[:human genes:c:chaf1a|CHAF1A]]|0.405|
|[[:human genes:a:atp13a1|ATP13A1]]|0.404|
|[[:human genes:c:cdc73|CDC73]]|0.403|
|[[:human genes:p:psmd14|PSMD14]]|0.402|
|[[:human genes:p:pan2|PAN2]]|0.4|
|[[:human genes:m:med17|MED17]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 713/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|23/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|19/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMC3 Expression in NALM6 Cells: 6.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>