======= PSMD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMD1
  * **<color #00a2e8>Official Name</color>**: proteasome 26S subunit, non-ATPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5707|5707]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99460|Q99460]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617842|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PC rep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome storage granule|
|proteasome regulatory particle|
|proteasome regulatory particle, base subcomplex|
|enzyme regulator activity|
|proteasome accessory complex|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|endopeptidase activity|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|NIK/NF-kappaB signaling|
|regulation of cellular amine metabolic process|
|anaphase-promoting complex-dependent catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|azurophil granule lumen|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|negative regulation of canonical Wnt signaling pathway|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|antigen processing and presentation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|regulation of animal organ morphogenesis|
|activation of innate immune response|
|response to tumor necrosis factor|
|protein deubiquitination|
|regulation of canonical Wnt signaling pathway|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|response to oxygen levels|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of mitotic cell cycle|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulated exocytosis|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|exocytosis|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|leukocyte activation|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.58|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.49|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.06|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.87|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.78|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.72|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.75|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.76|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.78|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.79|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.79|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.81|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.81|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.85|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.85|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.88|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.9|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.95|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.96|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.07|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.12|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.14|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.15|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.19|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.27|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.31|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.45|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.45|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.52|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.61|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.78|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.81|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.93|
|[[:results:exp11|CCCP 1μM R00 exp11]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfand5|ZFAND5]]|0.591|
|[[:human genes:v:vasn|VASN]]|0.588|
|[[:human genes:p:psmd11|PSMD11]]|0.573|
|[[:human genes:s:smg1|SMG1]]|0.568|
|[[:human genes:d:ddtl|DDTL]]|0.567|
|[[:human genes:p:psmc1|PSMC1]]|0.565|
|[[:human genes:p:psmd3|PSMD3]]|0.563|
|[[:human genes:p:psmd13|PSMD13]]|0.561|
|[[:human genes:h:hap1|HAP1]]|0.547|
|[[:human genes:m:mt1e|MT1E]]|0.539|
|[[:human genes:s:smg7|SMG7]]|0.539|
|[[:human genes:r:rps28|RPS28]]|0.535|
|[[:human genes:n:nupl1|NUPL1]]|0.534|
|[[:human genes:s:scaf1|SCAF1]]|0.534|
|[[:human genes:p:pan3|PAN3]]|0.534|
|[[:human genes:a:atp13a1|ATP13A1]]|0.532|
|[[:human genes:p:psmb4|PSMB4]]|0.532|
|[[:human genes:p:psma6|PSMA6]]|0.531|
|[[:human genes:r:rad21|RAD21]]|0.53|
|[[:human genes:z:znf106|ZNF106]]|0.529|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.526|
|[[:human genes:p:psmb1|PSMB1]]|0.526|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.524|
|[[:human genes:l:lrr1|LRR1]]|0.524|
|[[:human genes:k:kctd17|KCTD17]]|0.522|
|[[:human genes:p:psmc6|PSMC6]]|0.52|
|[[:human genes:c:cdc45|CDC45]]|0.514|
|[[:human genes:u:upf1|UPF1]]|0.513|
|[[:human genes:s:ssh2|SSH2]]|0.512|
|[[:human genes:c:cdc73|CDC73]]|0.512|
|[[:human genes:d:dnm2|DNM2]]|0.512|
|[[:human genes:i:igfn1|IGFN1]]|0.511|
|[[:human genes:t:terf2|TERF2]]|0.511|
|[[:human genes:r:rrm1|RRM1]]|0.507|
|[[:human genes:p:psma7|PSMA7]]|0.505|
|[[:human genes:r:rps9|RPS9]]|0.505|
|[[:human genes:s:supt6h|SUPT6H]]|0.503|
|[[:human genes:c:ccna2|CCNA2]]|0.503|
|[[:human genes:n:nup54|NUP54]]|0.502|
|[[:human genes:r:rps2|RPS2]]|0.501|
|[[:human genes:t:twistnb|TWISTNB]]|0.5|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.5|
|[[:human genes:r:rpsa|RPSA]]|0.499|
|[[:human genes:p:pole|POLE]]|0.498|
|[[:human genes:s:snrpa1|SNRPA1]]|0.497|
|[[:human genes:p:psmd6|PSMD6]]|0.497|
|[[:human genes:p:psmc2|PSMC2]]|0.497|
|[[:human genes:s:smg5|SMG5]]|0.493|
|[[:human genes:p:psma1|PSMA1]]|0.493|
|[[:human genes:r:rps12|RPS12]]|0.492|
|[[:human genes:p:psmd2|PSMD2]]|0.491|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.49|
|[[:human genes:c:ccdc94|CCDC94]]|0.49|
|[[:human genes:w:wdr87|WDR87]]|0.489|
|[[:human genes:p:paf1|PAF1]]|0.489|
|[[:human genes:r:rrp15|RRP15]]|0.489|
|[[:human genes:t:tceb3c|TCEB3C]]|0.487|
|[[:human genes:c:cope|COPE]]|0.486|
|[[:human genes:p:psmc4|PSMC4]]|0.484|
|[[:human genes:a:akirin2|AKIRIN2]]|0.483|
|[[:human genes:m:myo1h|MYO1H]]|0.483|
|[[:human genes:s:sfpq|SFPQ]]|0.482|
|[[:human genes:n:narfl|NARFL]]|0.477|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.477|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.475|
|[[:human genes:m:med17|MED17]]|0.472|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.471|
|[[:human genes:d:dtl|DTL]]|0.47|
|[[:human genes:c:ckap5|CKAP5]]|0.47|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.47|
|[[:human genes:k:kpnb1|KPNB1]]|0.469|
|[[:human genes:c:cwc22|CWC22]]|0.469|
|[[:human genes:t:top1mt|TOP1MT]]|0.469|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.469|
|[[:human genes:c:c14orf93|C14orf93]]|0.468|
|[[:human genes:p:polr2j3|POLR2J3]]|0.467|
|[[:human genes:r:rpl35|RPL35]]|0.467|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.467|
|[[:human genes:c:cdca3|CDCA3]]|0.467|
|[[:human genes:a:ankle2|ANKLE2]]|0.467|
|[[:human genes:m:mdm2|MDM2]]|0.467|
|[[:human genes:p:psmd14|PSMD14]]|0.466|
|[[:human genes:f:fbxo5|FBXO5]]|0.466|
|[[:human genes:p:pwp2|PWP2]]|0.464|
|[[:human genes:a:ahctf1|AHCTF1]]|0.464|
|[[:human genes:p:psmc3|PSMC3]]|0.464|
|[[:human genes:r:rrn3|RRN3]]|0.462|
|[[:human genes:o:orc1|ORC1]]|0.461|
|[[:human genes:s:s1pr4|S1PR4]]|0.46|
|[[:human genes:r:rpl26|RPL26]]|0.46|
|[[:human genes:d:ddt|DDT]]|0.458|
|[[:human genes:a:arcn1|ARCN1]]|0.457|
|[[:human genes:c:chd4|CHD4]]|0.457|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.455|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.454|
|[[:human genes:p:psmd7|PSMD7]]|0.454|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.454|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.453|
|[[:human genes:r:rbbp5|RBBP5]]|0.452|
|[[:human genes:a:adrm1|ADRM1]]|0.45|
|[[:human genes:c:chmp2a|CHMP2A]]|0.448|
|[[:human genes:r:rilpl1|RILPL1]]|0.448|
|[[:human genes:p:psmb2|PSMB2]]|0.447|
|[[:human genes:n:nop16|NOP16]]|0.447|
|[[:human genes:a:atxn1|ATXN1]]|0.447|
|[[:human genes:s:sf3a1|SF3A1]]|0.446|
|[[:human genes:r:rps19|RPS19]]|0.446|
|[[:human genes:c:cmya5|CMYA5]]|0.445|
|[[:human genes:h:hivep3|HIVEP3]]|0.445|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.445|
|[[:human genes:p:pola2|POLA2]]|0.444|
|[[:human genes:t:ticrr|TICRR]]|0.443|
|[[:human genes:i:iscu|ISCU]]|0.443|
|[[:human genes:n:nbpf10|NBPF10]]|0.443|
|[[:human genes:n:nol12|NOL12]]|0.442|
|[[:human genes:w:wdr43|WDR43]]|0.442|
|[[:human genes:m:myb|MYB]]|0.442|
|[[:human genes:n:nbpf16|NBPF16]]|0.44|
|[[:human genes:n:nol8|NOL8]]|0.44|
|[[:human genes:i:ints5|INTS5]]|0.439|
|[[:human genes:l:lad1|LAD1]]|0.439|
|[[:human genes:u:utp20|UTP20]]|0.437|
|[[:human genes:o:ogfr|OGFR]]|0.437|
|[[:human genes:c:cox8a|COX8A]]|0.436|
|[[:human genes:n:ndc1|NDC1]]|0.436|
|[[:human genes:r:ranbp2|RANBP2]]|0.435|
|[[:human genes:r:rbm39|RBM39]]|0.435|
|[[:human genes:d:disp2|DISP2]]|0.434|
|[[:human genes:g:golga8j|GOLGA8J]]|0.434|
|[[:human genes:p:pan2|PAN2]]|0.434|
|[[:human genes:c:cdt1|CDT1]]|0.433|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.433|
|[[:human genes:n:npipb8|NPIPB8]]|0.433|
|[[:human genes:p:prpf8|PRPF8]]|0.432|
|[[:human genes:r:rps20|RPS20]]|0.432|
|[[:human genes:c:cbwd5|CBWD5]]|0.431|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.431|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.431|
|[[:human genes:u:usp36|USP36]]|0.431|
|[[:human genes:t:tra2b|TRA2B]]|0.43|
|[[:human genes:c:ctr9|CTR9]]|0.429|
|[[:human genes:a:a2ml1|A2ML1]]|0.429|
|[[:human genes:f:fam160a1|FAM160A1]]|0.429|
|[[:human genes:n:nup133|NUP133]]|0.428|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.428|
|[[:human genes:s:sec13|SEC13]]|0.428|
|[[:human genes:n:nup160|NUP160]]|0.427|
|[[:human genes:b:bysl|BYSL]]|0.427|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.423|
|[[:human genes:s:slc38a7|SLC38A7]]|0.423|
|[[:human genes:p:pop1|POP1]]|0.423|
|[[:human genes:s:snip1|SNIP1]]|0.423|
|[[:human genes:t:traip|TRAIP]]|0.423|
|[[:human genes:d:ddx21|DDX21]]|0.423|
|[[:human genes:f:fbxw9|FBXW9]]|0.422|
|[[:human genes:p:psmc5|PSMC5]]|0.422|
|[[:human genes:z:znf830|ZNF830]]|0.422|
|[[:human genes:a:aaas|AAAS]]|0.421|
|[[:human genes:e:exosc5|EXOSC5]]|0.42|
|[[:human genes:r:rnf113a|RNF113A]]|0.42|
|[[:human genes:r:rad51|RAD51]]|0.419|
|[[:human genes:c:copg1|COPG1]]|0.419|
|[[:human genes:n:nup43|NUP43]]|0.419|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.419|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.419|
|[[:human genes:b:btk|BTK]]|0.419|
|[[:human genes:m:madcam1|MADCAM1]]|0.418|
|[[:human genes:c:ccdc116|CCDC116]]|0.417|
|[[:human genes:r:rps5|RPS5]]|0.417|
|[[:human genes:c:cdc6|CDC6]]|0.417|
|[[:human genes:a:akap1|AKAP1]]|0.417|
|[[:human genes:s:slc4a1|SLC4A1]]|0.416|
|[[:human genes:c:csnk1a1|CSNK1A1]]|0.415|
|[[:human genes:c:cbwd3|CBWD3]]|0.415|
|[[:human genes:r:rpl30|RPL30]]|0.414|
|[[:human genes:r:rpl8|RPL8]]|0.414|
|[[:human genes:s:sel1l|SEL1L]]|0.414|
|[[:human genes:x:xylt2|XYLT2]]|0.414|
|[[:human genes:r:rpl34|RPL34]]|0.413|
|[[:human genes:d:ddx56|DDX56]]|0.413|
|[[:human genes:k:krt36|KRT36]]|0.413|
|[[:human genes:t:tspy8|TSPY8]]|0.413|
|[[:human genes:c:clptm1|CLPTM1]]|0.412|
|[[:human genes:n:naaladl1|NAALADL1]]|0.412|
|[[:human genes:c:cgb2|CGB2]]|0.411|
|[[:human genes:o:orc6|ORC6]]|0.411|
|[[:human genes:n:nip7|NIP7]]|0.411|
|[[:human genes:p:psmb3|PSMB3]]|0.41|
|[[:human genes:p:pdcd11|PDCD11]]|0.409|
|[[:human genes:s:syt9|SYT9]]|0.407|
|[[:human genes:p:ppfia4|PPFIA4]]|0.406|
|[[:human genes:s:srsf1|SRSF1]]|0.405|
|[[:human genes:w:wdr75|WDR75]]|0.405|
|[[:human genes:r:rpl38|RPL38]]|0.405|
|[[:human genes:r:rps14|RPS14]]|0.404|
|[[:human genes:s:sf3a3|SF3A3]]|0.404|
|[[:human genes:z:znf655|ZNF655]]|0.404|
|[[:human genes:r:rfxank|RFXANK]]|0.404|
|[[:human genes:g:gnb3|GNB3]]|0.404|
|[[:human genes:i:ints6|INTS6]]|0.403|
|[[:human genes:c:col2a1|COL2A1]]|0.402|
|[[:human genes:n:npipb5|NPIPB5]]|0.401|
|[[:human genes:m:myt1l|MYT1L]]|0.401|
|[[:human genes:e:exosc9|EXOSC9]]|0.4|
|[[:human genes:c:copb1|COPB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 614/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|26/28|
|bone|20/26|
|breast|29/33|
|central nervous system|47/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|16/21|
|liver|18/20|
|lung|57/75|
|lymphocyte|13/16|
|ovary|24/26|
|pancreas|19/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|21/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 249
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMD1 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>