======= PSMD10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMD10
  * **<color #00a2e8>Official Name</color>**: proteasome 26S subunit, non-ATPase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5716|5716]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75832|O75832]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMD10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMD10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome regulatory particle assembly|
|cytoplasmic sequestering of NF-kappaB|
|proteasome regulatory particle, base subcomplex|
|proteasome assembly|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|cytoplasmic sequestering of transcription factor|
|negative regulation of release of cytochrome c from mitochondria|
|cytoplasmic sequestering of protein|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of signal transduction by p53 class mediator|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cyclin-dependent protein kinase activity|
|intermediate filament cytoskeleton|
|regulation of release of cytochrome c from mitochondria|
|negative regulation of mitochondrion organization|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|NIK/NF-kappaB signaling|
|regulation of cellular amine metabolic process|
|negative regulation of response to DNA damage stimulus|
|anaphase-promoting complex-dependent catabolic process|
|negative regulation of NF-kappaB transcription factor activity|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cell cycle G2/M phase transition|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of proteasomal protein catabolic process|
|maintenance of protein location|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|positive regulation of protein ubiquitination|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|positive regulation of canonical Wnt signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of cell growth|
|maintenance of location|
|negative regulation of MAPK cascade|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|negative regulation of canonical Wnt signaling pathway|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of mitochondrion organization|
|regulation of morphogenesis of an epithelium|
|regulation of signal transduction by p53 class mediator|
|antigen processing and presentation of exogenous antigen|
|regulation of proteasomal protein catabolic process|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of protein ubiquitination|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|antigen processing and presentation|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|regulation of cellular protein catabolic process|
|regulation of animal organ morphogenesis|
|activation of innate immune response|
|positive regulation of growth|
|response to tumor necrosis factor|
|protein deubiquitination|
|regulation of canonical Wnt signaling pathway|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|transcription factor binding|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|regulation of growth|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/26|
|bone|0/26|
|breast|1/30|
|central nervous system|2/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|2/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMD10 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>