======= PTEN =======
== Gene Information ==
* **Official Symbol**: PTEN
* **Official Name**: phosphatase and tensin homolog
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5728|5728]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P60484|P60484]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=PTEN&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTEN|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/601728|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].
* **UniProt Summary**: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. {ECO:0000269|PubMed:26504226}.
|DSPc|
|PTEN C2|
|negative regulation of synaptic vesicle clustering|
|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|
|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|
|negative regulation of keratinocyte migration|
|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|
|positive regulation of TRAIL-activated apoptotic signaling pathway|
|regulation of TRAIL-activated apoptotic signaling pathway|
|negative regulation of wound healing, spreading of epidermal cells|
|negative regulation of ribosome biogenesis|
|rhythmic synaptic transmission|
|central nervous system myelin maintenance|
|regulation of wound healing, spreading of epidermal cells|
|male mating behavior|
|myelin sheath adaxonal region|
|negative regulation of dendritic spine morphogenesis|
|postsynaptic density assembly|
|anaphase-promoting complex binding|
|neuron-neuron synaptic transmission|
|negative regulation of myelination|
|regulation of synaptic vesicle clustering|
|postsynaptic specialization assembly|
|cellular response to insulin-like growth factor stimulus|
|negative regulation of excitatory postsynaptic potential|
|negative regulation of cell size|
|presynaptic membrane assembly|
|Schmidt-Lanterman incisure|
|presynaptic membrane organization|
|prostate gland growth|
|forebrain morphogenesis|
|positive regulation of ubiquitin protein ligase activity|
|phosphatidylinositol-3-phosphatase activity|
|locomotor rhythm|
|synapse maturation|
|cellular response to electrical stimulus|
|negative regulation of axon regeneration|
|positive regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell apoptotic process|
|negative regulation of dendritic spine development|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|maternal behavior|
|parental behavior|
|negative regulation of cardiac muscle cell proliferation|
|cellular response to ethanol|
|inositol phosphate dephosphorylation|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|myelin maintenance|
|regulation of keratinocyte migration|
|excitatory synapse assembly|
|regulation of ribosome biogenesis|
|negative regulation of neuron projection regeneration|
|platelet-derived growth factor receptor binding|
|prepulse inhibition|
|phosphorylated carbohydrate dephosphorylation|
|negative regulation of morphogenesis of an epithelium|
|dentate gyrus development|
|negative regulation of dendrite morphogenesis|
|inositol phosphate catabolic process|
|ubiquitin-specific protease binding|
|regulation of B cell apoptotic process|
|long-term synaptic depression|
|postsynaptic density organization|
|postsynaptic cytosol|
|negative regulation of focal adhesion assembly|
|postsynaptic specialization organization|
|cellular response to leptin stimulus|
|dendritic spine morphogenesis|
|negative regulation of vascular smooth muscle cell proliferation|
|postsynapse assembly|
|presynapse assembly|
|axon ensheathment in central nervous system|
|central nervous system myelination|
|negative regulation of potassium ion transmembrane transporter activity|
|negative regulation of phagocytosis|
|mating behavior|
|negative regulation of adherens junction organization|
|phosphatidylinositol dephosphorylation|
|regulation of ubiquitin protein ligase activity|
|response to leptin|
|presynapse organization|
|circadian behavior|
|negative regulation of cell junction assembly|
|negative regulation of cardiac muscle tissue growth|
|negative regulation of heart growth|
|rhythmic behavior|
|negative regulation of cell aging|
|negative regulation of synapse organization|
|negative regulation of potassium ion transmembrane transport|
|polyol catabolic process|
|regulation of axon regeneration|
|negative regulation of nervous system process|
|protein tyrosine kinase binding|
|startle response|
|negative regulation of epithelial to mesenchymal transition|
|positive regulation of excitatory postsynaptic potential|
|positive regulation of muscle cell apoptotic process|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of neuron projection regeneration|
|dendritic spine development|
|negative regulation of dendrite development|
|regulation of myeloid cell apoptotic process|
|reproductive behavior|
|negative regulation of cyclin-dependent protein kinase activity|
|negative regulation of organ growth|
|dendritic spine organization|
|response to ATP|
|regulation of synaptic transmission, GABAergic|
|positive regulation of ubiquitin-protein transferase activity|
|response to arsenic-containing substance|
|negative regulation of cardiac muscle tissue development|
|negative regulation of potassium ion transport|
|ionotropic glutamate receptor binding|
|brain morphogenesis|
|mating|
|platelet-derived growth factor receptor signaling pathway|
|membrane assembly|
|phospholipid dephosphorylation|
|central nervous system neuron axonogenesis|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of cell-matrix adhesion|
|protein kinase B signaling|
|regulation of striated muscle cell apoptotic process|
|membrane biogenesis|
|neuron projection organization|
|regulation of cardiac muscle cell proliferation|
|modulation of excitatory postsynaptic potential|
|phosphoprotein phosphatase activity|
|prostate gland development|
|regulation of myelination|
|protein tyrosine/serine/threonine phosphatase activity|
|oligodendrocyte development|
|response to electrical stimulus|
|regulation of dendritic spine morphogenesis|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of protein kinase B signaling|
|long-term synaptic potentiation|
|negative regulation of striated muscle tissue development|
|regulation of cell aging|
|negative regulation of muscle organ development|
|positive regulation of extrinsic apoptotic signaling pathway|
|cellular response to nerve growth factor stimulus|
|regulation of vascular smooth muscle cell proliferation|
|negative regulation of muscle tissue development|
|regulation of ubiquitin-protein transferase activity|
|social behavior|
|response to nerve growth factor|
|regulation of lymphocyte apoptotic process|
|intraspecies interaction between organisms|
|cytoplasmic side of plasma membrane|
|response to zinc ion|
|alcohol catabolic process|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of potassium ion transmembrane transporter activity|
|inositol phosphate metabolic process|
|regulation of cardiac muscle tissue growth|
|dendrite morphogenesis|
|negative regulation of signaling receptor activity|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of synaptic transmission|
|negative regulation of cell-substrate adhesion|
|positive regulation of nervous system process|
|regulation of heart growth|
|protein serine/threonine phosphatase activity|
|response to activity|
|endothelial cell migration|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|regulation of adherens junction organization|
|multi-organism behavior|
|regulation of muscle cell apoptotic process|
|multicellular organismal response to stress|
|oligodendrocyte differentiation|
|negative regulation of axonogenesis|
|negative regulation of wound healing|
|negative regulation of ion transmembrane transporter activity|
|regulation of dendritic spine development|
|organic hydroxy compound catabolic process|
|negative regulation of transporter activity|
|regulation of cardiac muscle tissue development|
|central nervous system neuron development|
|regulation of potassium ion transmembrane transport|
|hippocampus development|
|negative regulation of cation transmembrane transport|
|regulation of leukocyte apoptotic process|
|epithelial cell migration|
|regulation of epithelial to mesenchymal transition|
|cellular response to alcohol|
|negative regulation of response to wounding|
|epithelium migration|
|PDZ domain binding|
|postsynapse organization|
|regulation of cell junction assembly|
|canonical Wnt signaling pathway|
|regulation of dendrite morphogenesis|
|plasma membrane organization|
|synapse assembly|
|tissue migration|
|regulation of organ growth|
|regulation of phagocytosis|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|regulation of postsynapse organization|
|organ growth|
|negative regulation of cell morphogenesis involved in differentiation|
|cell projection|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|protein tyrosine phosphatase activity|
|PML body|
|dendrite development|
|regulation of cyclin-dependent protein kinase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of developmental growth|
|myelination|
|negative regulation of cell cycle G1/S phase transition|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|neuromuscular process|
|phosphatidylinositol biosynthetic process|
|limbic system development|
|polyol metabolic process|
|regulation of synaptic vesicle cycle|
|regulation of cell-matrix adhesion|
|positive regulation of protein ubiquitination|
|negative regulation of transmembrane transport|
|cellular response to antibiotic|
|memory|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of epithelial cell proliferation|
|response to ethanol|
|organophosphate catabolic process|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|negative regulation of protein serine/threonine kinase activity|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of muscle tissue development|
|response to organophosphorus|
|regulation of muscle organ development|
|response to estradiol|
|regulation of nervous system process|
|response to glucose|
|regulation of wound healing|
|positive regulation of cellular protein catabolic process|
|circadian rhythm|
|response to hexose|
|adult behavior|
|negative regulation of ion transport|
|response to monosaccharide|
|dendritic spine|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|response to purine-containing compound|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|negative regulation of neuron projection development|
|lipid binding|
|cardiac muscle tissue development|
|cellular response to insulin stimulus|
|regulation of cell cycle G1/S phase transition|
|negative regulation of MAPK cascade|
|regulation of response to wounding|
|phosphatidylinositol metabolic process|
|glial cell differentiation|
|cellular carbohydrate metabolic process|
|ameboidal-type cell migration|
|response to carbohydrate|
|regulation of signaling receptor activity|
|pallium development|
|positive regulation of apoptotic signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|protein stabilization|
|central nervous system neuron differentiation|
|regulation of morphogenesis of an epithelium|
|negative regulation of cell projection organization|
|regulation of cell size|
|regulation of axonogenesis|
|cellular response to hypoxia|
|regulation of synaptic plasticity|
|locomotory behavior|
|cellular response to decreased oxygen levels|
|regulation of protein ubiquitination|
|postsynaptic membrane|
|lipid modification|
|glycerophospholipid biosynthetic process|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to toxic substance|
|gliogenesis|
|protein dephosphorylation|
|cellular response to oxygen levels|
|response to nutrient|
|regulation of proteolysis involved in cellular protein catabolic process|
|DNA-templated transcription, initiation|
|positive regulation of protein catabolic process|
|regulation of synapse organization|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|glycerolipid biosynthetic process|
|negative regulation of neuron differentiation|
|negative regulation of protein kinase activity|
|response to insulin|
|regulation of synapse structure or activity|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|response to alcohol|
|developmental maturation|
|negative regulation of growth|
|negative regulation of kinase activity|
|phospholipid biosynthetic process|
|regulation of cellular protein catabolic process|
|telencephalon development|
|regulation of ion transmembrane transporter activity|
|negative regulation of cell migration|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|regulation of transmembrane transporter activity|
|cellular response to peptide hormone stimulus|
|synapse organization|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|rhythmic process|
|negative regulation of transferase activity|
|regulation of transporter activity|
|aging|
|protein deubiquitination|
|striated muscle tissue development|
|regulation of protein stability|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|muscle tissue development|
|protein modification by small protein removal|
|cognition|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of mitotic cell cycle|
|glycerophospholipid metabolic process|
|negative regulation of cellular component movement|
|dephosphorylation|
|negative regulation of nervous system development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|angiogenesis|
|alcohol metabolic process|
|urogenital system development|
|apical plasma membrane|
|neuron projection|
|negative regulation of locomotion|
|negative regulation of cell cycle process|
|cellular response to peptide|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|regulation of cation transmembrane transport|
|negative regulation of cell development|
|response to hypoxia|
|enzyme binding|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|Wnt signaling pathway|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|response to metal ion|
|axonogenesis|
|phospholipid metabolic process|
|regulation of cellular component size|
|glycerolipid metabolic process|
|response to oxygen levels|
|regulation of protein catabolic process|
|forebrain development|
|regulation of metal ion transport|
|developmental growth|
|response to peptide hormone|
|growth|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|axon development|
|gland development|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of catabolic process|
|trans-synaptic signaling|
|small molecule catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|positive regulation of neurogenesis|
|response to peptide|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|blood vessel development|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|heart development|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|organophosphate biosynthetic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|behavior|
|negative regulation of cell cycle|
|lipid biosynthetic process|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|brain development|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|organelle assembly|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|membrane organization|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
|positive regulation of gene expression|
|gene expression|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.75|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.71|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.67|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.55|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.43|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.36|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.35|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.25|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.19|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.18|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.02|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.98|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.97|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.97|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.94|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.91|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.91|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.88|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.85|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.84|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.83|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.8|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.8|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.75|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.73|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.78|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.81|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.97|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.19|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.23|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.32|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|3.13|
|[[:results:exp504|MK2206 4μM R08 exp504]]|6.76|
^Gene^Correlation^
|[[:human genes:c:csk|CSK]]|0.572|
|[[:human genes:f:foxo1|FOXO1]]|0.527|
|[[:human genes:p:pag1|PAG1]]|0.457|
|[[:human genes:p:plekha2|PLEKHA2]]|0.438|
|[[:human genes:s:spi1|SPI1]]|0.404|
|[[:human genes:s:stk11|STK11]]|0.403|
|[[:human genes:i:irf4|IRF4]]|0.4|
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 2640
* **Expression level (log2 read counts)**: 7.65
{{:chemogenomics:nalm6 dist.png?nolink |}}