======= PTGS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGS1
  * **<color #00a2e8>Official Name</color>**: prostaglandin-endoperoxide synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5742|5742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23219|P23219]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|An peroxidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prostaglandin-endoperoxide synthase activity|
|cyclooxygenase pathway|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|dioxygenase activity|
|peroxidase activity|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|arachidonic acid metabolic process|
|photoreceptor outer segment|
|cellular oxidant detoxification|
|fatty acid derivative biosynthetic process|
|cellular detoxification|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|detoxification|
|xenobiotic metabolic process|
|heme binding|
|fatty acid derivative metabolic process|
|regulation of blood pressure|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|cellular response to toxic substance|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|response to oxidative stress|
|blood circulation|
|circulatory system process|
|inflammatory response|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|Golgi apparatus|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|defense response|
|regulation of cell population proliferation|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.72|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16842
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGS1 Expression in NALM6 Cells: 0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>