======= PTH1R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTH1R
  * **<color #00a2e8>Official Name</color>**: parathyroid hormone 1 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5745|5745]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q03431|Q03431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTH1R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTH1R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/168468|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:8397094}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|parathyroid hormone receptor activity|
|positive regulation of inositol phosphate biosynthetic process|
|regulation of inositol phosphate biosynthetic process|
|osteoblast development|
|bone resorption|
|positive regulation of alcohol biosynthetic process|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|bone remodeling|
|bone mineralization|
|brush border membrane|
|protein self-association|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of alcohol biosynthetic process|
|positive regulation of carbohydrate metabolic process|
|chondrocyte differentiation|
|biomineralization|
|biomineral tissue development|
|regulation of carbohydrate biosynthetic process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|tissue remodeling|
|osteoblast differentiation|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|cAMP-mediated signaling|
|cell maturation|
|cartilage development|
|cyclic-nucleotide-mediated signaling|
|tissue homeostasis|
|basolateral plasma membrane|
|regulation of carbohydrate metabolic process|
|receptor complex|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|connective tissue development|
|developmental maturation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|ossification|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|apical plasma membrane|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|anatomical structure homeostasis|
|in utero embryonic development|
|regulation of small molecule metabolic process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|skeletal system development|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|chordate embryonic development|
|cellular ion homeostasis|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|protein homodimerization activity|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|embryo development|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of cell population proliferation|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6053
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTH1R Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>