======= PTPMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPMT1
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase mitochondrial 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114971|114971]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUK0|Q8WUK0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylglycerophosphatase activity|
|cardiolipin biosynthetic process|
|phosphatidylglycerol biosynthetic process|
|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|
|cardiolipin metabolic process|
|phosphatidylglycerol metabolic process|
|protein tyrosine/serine/threonine phosphatase activity|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|regulation of intrinsic apoptotic signaling pathway|
|glycerophospholipid biosynthetic process|
|protein dephosphorylation|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|dephosphorylation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.15|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.77|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.7|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.7|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.77|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.77|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.79|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.81|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.83|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.84|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.86|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.87|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.9|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.93|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.02|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.05|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.06|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.06|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.11|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.13|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.15|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.16|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.22|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.25|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.26|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.28|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.29|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.35|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.41|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.43|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.43|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.45|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.48|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.59|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.66|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.66|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.68|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.82|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.86|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.98|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|3.48|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|4.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnlz|DNLZ]]|0.64|
|[[:human genes:p:pgm3|PGM3]]|0.545|
|[[:human genes:p:pmvk|PMVK]]|0.538|
|[[:human genes:t:trmt61a|TRMT61A]]|0.526|
|[[:human genes:d:dhrsx|DHRSX]]|0.514|
|[[:human genes:p:pgs1|PGS1]]|0.507|
|[[:human genes:p:pars2|PARS2]]|0.486|
|[[:human genes:g:gatc|GATC]]|0.472|
|[[:human genes:p:ppcdc|PPCDC]]|0.467|
|[[:human genes:d:dap3|DAP3]]|0.461|
|[[:human genes:r:romo1|ROMO1]]|0.449|
|[[:human genes:n:nars2|NARS2]]|0.445|
|[[:human genes:t:trmt6|TRMT6]]|0.445|
|[[:human genes:m:mrpl21|MRPL21]]|0.44|
|[[:human genes:c:coq3|COQ3]]|0.438|
|[[:human genes:y:yars2|YARS2]]|0.433|
|[[:human genes:m:mrps35|MRPS35]]|0.429|
|[[:human genes:g:g6pd|G6PD]]|0.428|
|[[:human genes:l:lsm10|LSM10]]|0.427|
|[[:human genes:r:rars2|RARS2]]|0.426|
|[[:human genes:f:fastkd5|FASTKD5]]|0.421|
|[[:human genes:l:lars2|LARS2]]|0.417|
|[[:human genes:a:aars2|AARS2]]|0.416|
|[[:human genes:m:mrpl23|MRPL23]]|0.415|
|[[:human genes:e:ears2|EARS2]]|0.415|
|[[:human genes:t:tamm41|TAMM41]]|0.415|
|[[:human genes:t:tmem242|TMEM242]]|0.414|
|[[:human genes:o:opa1|OPA1]]|0.413|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.41|
|[[:human genes:t:tars2|TARS2]]|0.41|
|[[:human genes:f:fh|FH]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 184/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|6/28|
|bone|12/26|
|breast|7/33|
|central nervous system|21/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|4/16|
|kidney|6/21|
|liver|8/20|
|lung|20/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|10/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 626
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPMT1 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>