======= PTPN12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPN12
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase non-receptor type 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5782|5782]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05209|Q05209]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPN12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPN12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600079|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|
|regulation of platelet-derived growth factor receptor-beta signaling pathway|
|non-membrane spanning protein tyrosine phosphatase activity|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of platelet-derived growth factor receptor signaling pathway|
|podosome|
|ERBB2 signaling pathway|
|phosphoprotein phosphatase activity|
|cellular response to epidermal growth factor stimulus|
|response to epidermal growth factor|
|negative regulation of ERBB signaling pathway|
|tissue regeneration|
|ERBB signaling pathway|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of ERBB signaling pathway|
|cell projection|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|SH3 domain binding|
|regeneration|
|protein dephosphorylation|
|dephosphorylation|
|developmental growth|
|growth|
|focal adhesion|
|wound healing|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|response to wounding|
|enzyme linked receptor protein signaling pathway|
|cellular response to cytokine stimulus|
|response to cytokine|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|negative regulation of response to stimulus|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11060
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPN12 Expression in NALM6 Cells: 4.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>