======= PTPRJ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRJ
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type J
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5795|5795]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12913|Q12913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRJ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRJ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600925|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. {ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:16778204, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Y phosphatase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|delta-catenin binding|
|positive regulation of Fc receptor mediated stimulatory signaling pathway|
|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|contact inhibition|
|gamma-catenin binding|
|negative regulation of vascular permeability|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|platelet-derived growth factor receptor binding|
|negative regulation of T cell receptor signaling pathway|
|mitogen-activated protein kinase binding|
|regulation of platelet-derived growth factor receptor signaling pathway|
|calcium-mediated signaling using intracellular calcium source|
|positive regulation of focal adhesion assembly|
|negative regulation of antigen receptor-mediated signaling pathway|
|positive regulation of adherens junction organization|
|platelet-derived growth factor receptor signaling pathway|
|positive regulation of cell junction assembly|
|regulation of vascular permeability|
|immunological synapse|
|regulation of T cell receptor signaling pathway|
|negative regulation of protein kinase B signaling|
|negative regulation of epidermal growth factor receptor signaling pathway|
|phosphatase activity|
|positive chemotaxis|
|negative regulation of ERBB signaling pathway|
|positive regulation of cell-matrix adhesion|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of adherens junction organization|
|positive regulation of phagocytosis|
|negative regulation of MAP kinase activity|
|beta-catenin binding|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of cell junction assembly|
|regulation of ERBB signaling pathway|
|specific granule membrane|
|regulation of phagocytosis|
|ruffle membrane|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|B cell differentiation|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|negative regulation of protein serine/threonine kinase activity|
|calcium-mediated signaling|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|B cell activation|
|positive regulation of protein kinase B signaling|
|negative regulation of MAPK cascade|
|vascular process in circulatory system|
|cell-cell junction|
|T cell receptor signaling pathway|
|negative regulation of cell growth|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of cell-substrate adhesion|
|protein dephosphorylation|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|negative regulation of protein kinase activity|
|lymphocyte differentiation|
|negative regulation of growth|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|antigen receptor-mediated signaling pathway|
|dephosphorylation|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of locomotion|
|leukocyte differentiation|
|second-messenger-mediated signaling|
|regulation of MAP kinase activity|
|lymphocyte activation|
|blood circulation|
|circulatory system process|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|regulation of cell growth|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|protein kinase binding|
|regulation of immune effector process|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|positive regulation of MAPK cascade|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|immune system development|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|leukocyte activation|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.17|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.05|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.81|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.86|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.48|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRJ Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>