======= PTPRK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRK
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5796|5796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15262|Q15262]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602545|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|MAM|
|Y phosphatase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leading edge membrane|
|gamma-catenin binding|
|negative regulation of keratinocyte proliferation|
|transmembrane receptor protein tyrosine phosphatase activity|
|protein localization to cell surface|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|regulation of keratinocyte proliferation|
|adherens junction assembly|
|cell-substrate junction assembly|
|photoreceptor outer segment|
|adherens junction|
|beta-catenin binding|
|cellular response to UV|
|adherens junction organization|
|protein tyrosine phosphatase activity|
|transforming growth factor beta receptor signaling pathway|
|peptidyl-tyrosine dephosphorylation|
|cellular response to light stimulus|
|negative regulation of epithelial cell proliferation|
|cell-matrix adhesion|
|cellular response to reactive oxygen species|
|response to UV|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cell junction assembly|
|cell-cell junction|
|cellular response to radiation|
|cell-substrate adhesion|
|response to reactive oxygen species|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell junction organization|
|protein dephosphorylation|
|cellular response to oxidative stress|
|negative regulation of cell migration|
|negative regulation of cell motility|
|axon|
|response to light stimulus|
|dephosphorylation|
|negative regulation of cellular component movement|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|neuronal cell body|
|response to oxidative stress|
|dendrite|
|response to radiation|
|protein kinase binding|
|cellular response to growth factor stimulus|
|response to growth factor|
|cell junction|
|negative regulation of cell cycle|
|cell surface|
|neuron projection development|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|enzyme linked receptor protein signaling pathway|
|neuron development|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|cellular response to stress|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.79|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.74|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4328
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRK Expression in NALM6 Cells: 3.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>