======= PTPRN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRN
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type N
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5798|5798]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16849|Q16849]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601773|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle- stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}. ICA512-cleaved cytosolic fragment: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Receptor IA-2|
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of type B pancreatic cell proliferation|
|dense core granule maturation|
|secretory granule maturation|
|insulin secretion involved in cellular response to glucose stimulus|
|luteinization|
|regulation of type B pancreatic cell proliferation|
|ubiquitin-like protein ligase binding|
|spectrin binding|
|GTPase binding|
|secretory granule organization|
|insulin secretion|
|transport vesicle membrane|
|ovulation cycle process|
|axon terminus|
|peptide hormone secretion|
|ovulation cycle|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|hormone secretion|
|cellular response to monosaccharide stimulus|
|response to estrogen|
|cellular response to carbohydrate stimulus|
|hormone transport|
|secretory granule|
|female gonad development|
|cellular glucose homeostasis|
|development of primary female sexual characteristics|
|response to cAMP|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|female sex differentiation|
|synaptic vesicle|
|perikaryon|
|response to organophosphorus|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to purine-containing compound|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|response to carbohydrate|
|peptide secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of epithelial cell proliferation|
|response to reactive oxygen species|
|gonad development|
|protein dephosphorylation|
|development of primary sexual characteristics|
|response to insulin|
|developmental maturation|
|sex differentiation|
|synapse|
|endosome|
|rhythmic process|
|vesicle organization|
|dephosphorylation|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|neuronal cell body|
|response to oxidative stress|
|response to peptide hormone|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|regulation of hormone levels|
|cell junction|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|cellular chemical homeostasis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|Golgi apparatus|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of transcription by RNA polymerase II|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.8|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.73|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.78|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.82|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.83|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.84|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRN Expression in NALM6 Cells: -0.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>