======= PTPRS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPRS
  * **<color #00a2e8>Official Name</color>**: protein tyrosine phosphatase receptor type S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5802|5802]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13332|Q13332]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPRS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPRS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). {ECO:0000250|UniProtKB:B0V2N1, ECO:0000250|UniProtKB:F1NWE3, ECO:0000269|PubMed:21454754, ECO:0000269|PubMed:26231120, ECO:0000269|PubMed:8524829}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Y phosphatase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of toll-like receptor 9 signaling pathway|
|negative regulation of interferon-alpha production|
|regulation of toll-like receptor 9 signaling pathway|
|negative regulation of collateral sprouting|
|chondroitin sulfate binding|
|regulation of postsynaptic density assembly|
|regulation of postsynaptic specialization assembly|
|regulation of postsynapse assembly|
|negative regulation of dendritic spine development|
|negative regulation of axon regeneration|
|regulation of excitatory synapse assembly|
|negative regulation of interferon-beta production|
|establishment of endothelial intestinal barrier|
|negative regulation of neuron projection regeneration|
|regulation of postsynaptic density organization|
|corpus callosum development|
|heparan sulfate proteoglycan binding|
|regulation of collateral sprouting|
|synaptic membrane adhesion|
|regulation of axon regeneration|
|negative regulation of dendrite development|
|regulation of neuron projection regeneration|
|regulation of interferon-alpha production|
|establishment of endothelial barrier|
|integral component of synaptic vesicle membrane|
|negative regulation of toll-like receptor signaling pathway|
|phosphoprotein phosphatase activity|
|negative regulation of axon extension|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|endothelial cell development|
|integral component of postsynaptic density membrane|
|integral component of presynaptic membrane|
|regulation of toll-like receptor signaling pathway|
|negative regulation of axonogenesis|
|regulation of dendritic spine development|
|hippocampus development|
|Schaffer collateral - CA1 synapse|
|endothelial cell differentiation|
|negative regulation of response to wounding|
|endothelium development|
|regulation of postsynapse organization|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|protein tyrosine phosphatase activity|
|cerebellum development|
|peptidyl-tyrosine dephosphorylation|
|regulation of synapse assembly|
|negative regulation of developmental growth|
|spinal cord development|
|limbic system development|
|regulation of extent of cell growth|
|metencephalon development|
|cerebral cortex development|
|regulation of type I interferon production|
|perikaryon|
|regulation of dendrite development|
|hindbrain development|
|negative regulation of neuron projection development|
|regulation of response to wounding|
|heparin binding|
|pallium development|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|epithelial cell development|
|protein dephosphorylation|
|regulation of synapse organization|
|regulation of organelle assembly|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|negative regulation of growth|
|telencephalon development|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse organization|
|negative regulation of cytokine production|
|negative regulation of neurogenesis|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|dephosphorylation|
|negative regulation of nervous system development|
|regulation of developmental growth|
|negative regulation of cell development|
|glutamatergic synapse|
|negative regulation of response to external stimulus|
|regulation of cellular component size|
|forebrain development|
|regulation of cell growth|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|regulation of innate immune response|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|regulation of anatomical structure size|
|regulation of response to biotic stimulus|
|cell junction|
|regulation of neuron differentiation|
|regulation of growth|
|epithelial cell differentiation|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|brain development|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|regulation of neurogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|epithelium development|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of response to stress|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.7|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.71|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.76|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.79|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10335
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPRS Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>