======= PTX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTX3
  * **<color #00a2e8>Official Name</color>**: pentraxin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5806|5806]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26022|P26022]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pentaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by host of viral exo-alpha-sialidase activity|
|negative regulation by host of viral exo-alpha-sialidase activity|
|modulation by host of viral glycoprotein metabolic process|
|(1->3)-beta-D-glucan binding|
|negative regulation by host of symbiont catalytic activity|
|modulation by host of viral catalytic activity|
|negative regulation by host of viral glycoprotein metabolic process|
|negative regulation of exo-alpha-sialidase activity|
|modulation by host of viral molecular function|
|ovarian cumulus expansion|
|regulation of exo-alpha-sialidase activity|
|negative regulation of catalytic activity in other organism involved in symbiotic interaction|
|fused antrum stage|
|modulation by host of symbiont catalytic activity|
|modulation of catalytic activity in other organism involved in symbiotic interaction|
|response to yeast|
|mammalian oogenesis stage|
|negative regulation by host of symbiont molecular function|
|antral ovarian follicle growth|
|modulation by host of symbiont molecular function|
|complement component C1q binding|
|negative regulation of molecular function in other organism|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|opsonization|
|modulation of molecular function in other organism|
|modulation of molecular function in other organism involved in symbiotic interaction|
|negative regulation by host of viral process|
|virion binding|
|negative regulation of glycoprotein metabolic process|
|negative regulation of viral entry into host cell|
|modulation by host of viral process|
|regulation of viral entry into host cell|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|ovulation cycle process|
|regulation of glycoprotein metabolic process|
|response to fungus|
|positive regulation of reactive oxygen species biosynthetic process|
|ovarian follicle development|
|tertiary granule lumen|
|regulation of nitric oxide biosynthetic process|
|specific granule lumen|
|ovulation cycle|
|positive regulation of phagocytosis|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|oogenesis|
|negative regulation of viral life cycle|
|regulation of reactive oxygen species biosynthetic process|
|female gonad development|
|development of primary female sexual characteristics|
|regulation of phagocytosis|
|positive regulation of reactive oxygen species metabolic process|
|negative regulation of viral process|
|female sex differentiation|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|female gamete generation|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|regulation of reactive oxygen species metabolic process|
|regulation of viral process|
|gonad development|
|negative regulation of multi-organism process|
|development of primary sexual characteristics|
|regulation of symbiosis, encompassing mutualism through parasitism|
|extracellular matrix|
|germ cell development|
|sex differentiation|
|rhythmic process|
|phagocytosis|
|extracellular matrix organization|
|regulation of neurotransmitter levels|
|cellular process involved in reproduction in multicellular organism|
|extracellular structure organization|
|developmental growth|
|growth|
|reproductive structure development|
|reproductive system development|
|negative regulation of hydrolase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|gamete generation|
|regulated exocytosis|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|exocytosis|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|leukocyte activation|
|defense response to other organism|
|positive regulation of transport|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|extracellular space|
|cell development|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.82|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.72|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12388
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTX3 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>