======= PUS7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PUS7
  * **<color #00a2e8>Official Name</color>**: pseudouridine synthase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54517|54517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PZ0|Q96PZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PUS7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PUS7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TruD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA pseudouridine synthesis|
|tRNA pseudouridine synthesis|
|pseudouridine synthase activity|
|regulation of mesoderm development|
|pseudouridine synthesis|
|mRNA modification|
|regulation of hematopoietic stem cell differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|tRNA modification|
|regulation of stem cell differentiation|
|negative regulation of translation|
|tRNA processing|
|negative regulation of cellular amide metabolic process|
|RNA modification|
|tRNA metabolic process|
|enzyme binding|
|regulation of translation|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|regulation of hemopoiesis|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|RNA processing|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|negative regulation of gene expression|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.76|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.61|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.58|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.4|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.21|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.17|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.14|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.06|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.01|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.98|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.83|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.04|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PUS7 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>