======= PXDN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PXDN
  * **<color #00a2e8>Official Name</color>**: peroxidasin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7837|7837]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92626|Q92626]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PXDN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PXDN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605158|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. {ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|An peroxidase|
|VWC|
|V-set|
|I-set|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bromide peroxidase activity|
|interleukin-1 receptor antagonist activity|
|basement membrane assembly|
|basement membrane organization|
|hydrogen peroxide catabolic process|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|collagen fibril organization|
|antibiotic catabolic process|
|negative regulation of cytokine-mediated signaling pathway|
|cofactor catabolic process|
|negative regulation of response to cytokine stimulus|
|cellular oxidant detoxification|
|cellular detoxification|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|detoxification|
|extracellular matrix structural constituent|
|heme binding|
|drug catabolic process|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|cellular response to toxic substance|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|response to oxidative stress|
|cofactor metabolic process|
|supramolecular fiber organization|
|drug metabolic process|
|response to toxic substance|
|oxidation-reduction process|
|endoplasmic reticulum|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|extracellular space|
|negative regulation of response to stimulus|
|cellular catabolic process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6850
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PXDN Expression in NALM6 Cells: 9.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>