======= PYCR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PYCR1
  * **<color #00a2e8>Official Name</color>**: pyrroline-5-carboxylate reductase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5831|5831]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32322|P32322]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PYCR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PYCR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD Gly3P dh N|
|F420 oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyrroline-5-carboxylate reductase activity|
|proline biosynthetic process|
|L-proline biosynthetic process|
|proline metabolic process|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|glutamine family amino acid biosynthetic process|
|negative regulation of cellular response to drug|
|regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to drug|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|regulation of oxidative stress-induced cell death|
|alpha-amino acid biosynthetic process|
|glutamine family amino acid metabolic process|
|regulation of mitochondrial membrane potential|
|regulation of cellular response to oxidative stress|
|cellular amino acid biosynthetic process|
|regulation of response to oxidative stress|
|regulation of response to drug|
|alpha-amino acid metabolic process|
|cellular response to oxidative stress|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|response to oxidative stress|
|regulation of membrane potential|
|drug metabolic process|
|small molecule biosynthetic process|
|regulation of cellular response to stress|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|heterocycle biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PYCR1 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>