======= RAB31 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB31
  * **<color #00a2e8>Official Name</color>**: RAB31, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11031|11031]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13636|Q13636]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB31&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB31|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605694|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|early phagosome membrane|
|positive regulation of phagocytosis, engulfment|
|positive regulation of membrane invagination|
|regulation of phagocytosis, engulfment|
|regulation of membrane invagination|
|phagocytic cup|
|Golgi to plasma membrane protein transport|
|phagosome maturation|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|phagocytic vesicle|
|receptor internalization|
|positive regulation of phagocytosis|
|Rab protein signal transduction|
|GDP binding|
|vesicle-mediated transport to the plasma membrane|
|trans-Golgi network membrane|
|regulation of phagocytosis|
|secretory granule membrane|
|positive regulation of endocytosis|
|post-Golgi vesicle-mediated transport|
|receptor metabolic process|
|early endosome membrane|
|cellular response to insulin stimulus|
|protein localization to plasma membrane|
|regulation of endocytosis|
|response to insulin|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|Ras protein signal transduction|
|early endosome|
|establishment of protein localization to membrane|
|cellular response to peptide hormone stimulus|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|GTPase activity|
|Golgi vesicle transport|
|GTP binding|
|response to peptide hormone|
|response to peptide|
|protein localization to membrane|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|endocytosis|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|import into cell|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|response to hormone|
|leukocyte activation|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17009
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB31 Expression in NALM6 Cells: 2.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>