======= RAB5C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB5C
  * **<color #00a2e8>Official Name</color>**: RAB5C, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5878|5878]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51148|P51148]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB5C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB5C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604037|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Gtr1 RagA|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane to endosome transport|
|endocytic vesicle|
|azurophil granule membrane|
|Rab protein signal transduction|
|GDP binding|
|lipid droplet|
|melanosome|
|early endosome membrane|
|regulation of endocytosis|
|Ras protein signal transduction|
|early endosome|
|endosome|
|lysosomal membrane|
|small GTPase mediated signal transduction|
|GTPase activity|
|GTP binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-3.66|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.4|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.28|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.85|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.82|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.82|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.73|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.76|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.99|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.09|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.14|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.25|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.485|
|[[:human genes:s:sh3gl1|SH3GL1]]|0.442|
|[[:human genes:v:vps8|VPS8]]|0.427|
|[[:human genes:v:vps45|VPS45]]|0.421|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.405|
|[[:human genes:a:ap2s1|AP2S1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2592
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB5C Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>