======= RAB7L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB29
  * **<color #00a2e8>Official Name</color>**: RAB29, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8934|8934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14966|O14966]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB7L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB7L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603949|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|symbiont-containing vacuole|
|multi-organism toxin transport|
|regulation of retrograde transport, endosome to Golgi|
|intracellular vesicle|
|protein localization to ciliary membrane|
|viral RNA genome replication|
|vacuole|
|positive regulation of T cell receptor signaling pathway|
|positive regulation of receptor recycling|
|dynein complex binding|
|positive regulation of antigen receptor-mediated signaling pathway|
|regulation of cytoplasmic transport|
|regulation of receptor recycling|
|viral genome replication|
|regulation of T cell receptor signaling pathway|
|toxin transport|
|kinesin binding|
|protein localization to cilium|
|regulation of antigen receptor-mediated signaling pathway|
|cis-Golgi network|
|multi-organism transport|
|multi-organism localization|
|Rab protein signal transduction|
|GDP binding|
|retrograde transport, endosome to Golgi|
|synapse assembly|
|melanosome|
|recycling endosome|
|Golgi organization|
|cytosolic transport|
|Rab GTPase binding|
|positive regulation of intracellular protein transport|
|negative regulation of neuron projection development|
|trans-Golgi network|
|negative regulation of cell projection organization|
|viral life cycle|
|positive regulation of intracellular transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|negative regulation of neuron differentiation|
|protein localization to cell periphery|
|endosomal transport|
|regulation of intracellular protein transport|
|T cell activation|
|Ras protein signal transduction|
|early endosome|
|synapse organization|
|negative regulation of neurogenesis|
|regulation of neuron death|
|negative regulation of nervous system development|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|GTPase activity|
|negative regulation of cell development|
|regulation of intracellular transport|
|cytoskeleton|
|Golgi vesicle transport|
|lymphocyte activation|
|GTP binding|
|endomembrane system organization|
|positive regulation of protein transport|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|regulation of neuron projection development|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|regulation of neuron differentiation|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|positive regulation of immune response|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|cell activation|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB7L1 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>