======= RAB8A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB8A
  * **<color #00a2e8>Official Name</color>**: RAB8A, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4218|4218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61006|P61006]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAB8A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAB8A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Plays an important role in ciliogenesis (PubMed:21844891). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P55258, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:27103069}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Gtr1 RagA|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi vesicle fusion to target membrane|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|neurotransmitter receptor transport, endosome to plasma membrane|
|endosome to plasma membrane protein transport|
|trans-Golgi network transport vesicle|
|myosin V binding|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|establishment of protein localization to postsynaptic membrane|
|regulation of long-term neuronal synaptic plasticity|
|retrograde transport, endosome to plasma membrane|
|non-motile cilium|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|ciliary base|
|receptor localization to synapse|
|vesicle docking involved in exocytosis|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment of protein localization to plasma membrane|
|regulation of neuronal synaptic plasticity|
|phagocytic vesicle|
|protein localization to synapse|
|vesicle docking|
|exocytic process|
|vesicle fusion|
|Rab protein signal transduction|
|phagocytic vesicle membrane|
|GDP binding|
|organelle membrane fusion|
|recycling endosome membrane|
|vesicle-mediated transport to the plasma membrane|
|trans-Golgi network membrane|
|organelle fusion|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|ciliary basal body|
|centriole|
|dendritic spine|
|Rab GTPase binding|
|midbody|
|protein secretion|
|establishment of protein localization to extracellular region|
|cellular response to insulin stimulus|
|protein localization to extracellular region|
|organelle localization by membrane tethering|
|peptide secretion|
|membrane docking|
|protein localization to plasma membrane|
|regulation of synaptic plasticity|
|cilium|
|regulation of exocytosis|
|response to insulin|
|protein localization to cell periphery|
|endosomal transport|
|Ras protein signal transduction|
|postsynaptic density|
|protein-containing complex localization|
|autophagy|
|process utilizing autophagic mechanism|
|establishment of protein localization to membrane|
|cellular response to peptide hormone stimulus|
|endosome|
|vesicle organization|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|GTPase activity|
|regulation of autophagy|
|cilium assembly|
|glutamatergic synapse|
|post-translational protein modification|
|cilium organization|
|neuronal cell body|
|axonogenesis|
|Golgi vesicle transport|
|GTP binding|
|response to peptide hormone|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein kinase binding|
|response to peptide|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|centrosome|
|cell part morphogenesis|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|organelle localization|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|Golgi membrane|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|exocytosis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|membrane organization|
|response to hormone|
|intracellular protein transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.73|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.85|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.58|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.76|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.78|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|4.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15667
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB8A Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>