======= RABGEF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RABGEF1
  * **<color #00a2e8>Official Name</color>**: RAB guanine nucleotide exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27342|27342]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJ41|Q9UJ41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RABGEF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RABGEF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). {ECO:0000250, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:15339665, ECO:0000269|PubMed:9323142}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-A20|
|VPS9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Kit signaling pathway|
|regulation of Kit signaling pathway|
|negative regulation of mast cell degranulation|
|negative regulation of mast cell activation involved in immune response|
|negative regulation of myeloid leukocyte mediated immunity|
|negative regulation of interleukin-6 secretion|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|negative regulation of leukocyte degranulation|
|negative regulation of mast cell activation|
|negative regulation of receptor-mediated endocytosis|
|negative regulation of regulated secretory pathway|
|negative regulation of exocytosis|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|Rab guanyl-nucleotide exchange factor activity|
|negative regulation of interleukin-6 production|
|negative regulation of endocytosis|
|regulation of mast cell activation|
|negative regulation of leukocyte migration|
|negative regulation of leukocyte mediated immunity|
|regulation of leukocyte degranulation|
|negative regulation of Ras protein signal transduction|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of small GTPase mediated signal transduction|
|negative regulation of intracellular transport|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|negative regulation of cytokine secretion|
|regulation of receptor-mediated endocytosis|
|recycling endosome|
|negative regulation of immune effector process|
|negative regulation of protein secretion|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|negative regulation of immune response|
|Rab GTPase binding|
|early endosome membrane|
|protein targeting to membrane|
|regulation of cytokine-mediated signaling pathway|
|regulation of regulated secretory pathway|
|negative regulation of leukocyte activation|
|regulation of response to cytokine stimulus|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of endocytosis|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|positive regulation of immune effector process|
|ubiquitin protein ligase activity|
|regulation of exocytosis|
|negative regulation of secretion|
|regulation of Ras protein signal transduction|
|early endosome|
|negative regulation of cell migration|
|establishment of protein localization to membrane|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of inflammatory response|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|protein targeting|
|negative regulation of response to external stimulus|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of protein secretion|
|regulation of immune effector process|
|protein localization to membrane|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|regulation of vesicle-mediated transport|
|endocytosis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|regulation of cell activation|
|import into cell|
|protein ubiquitination|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of secretion|
|zinc ion binding|
|regulation of cell migration|
|nucleolus|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of cellular component movement|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|DNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-2.6|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.27|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.12|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.07|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.98|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.95|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.92|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.8|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.78|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.07|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aagab|AAGAB]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RABGEF1 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>