======= RAC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAC2
  * **<color #00a2e8>Official Name</color>**: Rac family small GTPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5880|5880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15153|P15153]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602049|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. {ECO:0000269|PubMed:1660188}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lymphocyte aggregation|
|regulation of mast cell chemotaxis|
|protein kinase regulator activity|
|leukocyte aggregation|
|regulation of respiratory burst|
|positive regulation of lamellipodium assembly|
|regulation of hydrogen peroxide metabolic process|
|Rac protein signal transduction|
|positive regulation of neutrophil chemotaxis|
|bone resorption|
|positive regulation of granulocyte chemotaxis|
|positive regulation of lamellipodium organization|
|motor neuron axon guidance|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|regulation of lamellipodium assembly|
|positive regulation of protein targeting to mitochondrion|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|regulation of neutrophil migration|
|regulation of cofactor metabolic process|
|regulation of lamellipodium organization|
|regulation of granulocyte chemotaxis|
|regulation of protein targeting to mitochondrion|
|regulation of mast cell activation|
|bone remodeling|
|regulation of leukocyte degranulation|
|leukocyte cell-cell adhesion|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of myeloid leukocyte mediated immunity|
|regulation of establishment of protein localization to mitochondrion|
|phagocytic vesicle membrane|
|cell redox homeostasis|
|Rho protein signal transduction|
|actin filament|
|regulation of protein targeting|
|positive regulation of leukocyte chemotaxis|
|cell projection|
|tissue remodeling|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of leukocyte chemotaxis|
|positive regulation of mitochondrion organization|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|positive regulation of intracellular protein transport|
|regulation of T cell proliferation|
|regulation of regulated secretory pathway|
|positive regulation of protein kinase B signaling|
|nuclear envelope|
|lamellipodium|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|tissue homeostasis|
|regulation of leukocyte migration|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|regulation of exocytosis|
|regulation of intracellular protein transport|
|actin filament organization|
|Ras protein signal transduction|
|cytoplasmic vesicle|
|axon guidance|
|neuron projection guidance|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|GTPase activity|
|anatomical structure homeostasis|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|axonogenesis|
|positive regulation of cell projection organization|
|GTP binding|
|axon development|
|focal adhesion|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of immune effector process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|cell-cell adhesion|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|regulation of cell activation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.24|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.76|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAC2 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>