======= RAD18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD18
  * **<color #00a2e8>Official Name</color>**: RAD18 E3 ubiquitin protein ligase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56852|56852]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS91|Q9NS91]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605256|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAP|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rad6-Rad18 complex|
|Y-form DNA binding|
|nuclear inclusion body|
|single-stranded DNA helicase activity|
|replication fork|
|positive regulation of chromosome segregation|
|polyubiquitin modification-dependent protein binding|
|DNA damage response, detection of DNA damage|
|postreplication repair|
|damaged DNA binding|
|site of double-strand break|
|protein monoubiquitination|
|protein autoubiquitination|
|regulation of chromosome segregation|
|single-stranded DNA binding|
|DNA duplex unwinding|
|DNA geometric change|
|response to UV|
|ubiquitin protein ligase activity|
|protein-containing complex binding|
|nuclear body|
|ubiquitin protein ligase binding|
|DNA conformation change|
|response to light stimulus|
|response to radiation|
|centrosome|
|DNA repair|
|protein ubiquitination|
|detection of stimulus|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|chromosome organization|
|identical protein binding|
|response to abiotic stimulus|
|regulation of cell death|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.95|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.71|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.74|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.86|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12419
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD18 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>