======= RAD21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD21
  * **<color #00a2e8>Official Name</color>**: RAD21 cohesin complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5885|5885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60216|O60216]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606462|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad21 Rec8|
|Rad21 Rec8 N|
|ScpA ScpB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic cohesin complex|
|positive regulation of sister chromatid cohesion|
|cohesin complex|
|regulation of sister chromatid cohesion|
|negative regulation of mitotic metaphase/anaphase transition|
|protein localization to chromatin|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|positive regulation of chromosome segregation|
|condensed nuclear chromosome|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|sister chromatid cohesion|
|reciprocal meiotic recombination|
|regulation of mitotic metaphase/anaphase transition|
|homologous recombination|
|regulation of metaphase/anaphase transition of cell cycle|
|chromosome, centromeric region|
|regulation of mitotic sister chromatid separation|
|protein localization to chromosome|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|negative regulation of G2/M transition of mitotic cell cycle|
|negative regulation of cell cycle G2/M phase transition|
|regulation of chromosome segregation|
|nuclear matrix|
|meiosis I|
|meiosis I cell cycle process|
|chromatin|
|spindle pole|
|chromosome|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|meiotic nuclear division|
|meiotic cell cycle process|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|double-strand break repair|
|regulation of nuclear division|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|organelle fission|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|DNA repair|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|negative regulation of cellular component organization|
|protein localization to organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|apoptotic process|
|cell cycle process|
|programmed cell death|
|chromosome organization|
|cell death|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-3.17|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.22|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.01|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.01|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.9|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.71|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.75|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.75|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.77|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.81|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.95|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.04|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.17|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.33|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:upf1|UPF1]]|0.541|
|[[:human genes:m:mt1e|MT1E]]|0.539|
|[[:human genes:p:psmd1|PSMD1]]|0.53|
|[[:human genes:p:psmd3|PSMD3]]|0.52|
|[[:human genes:p:prim1|PRIM1]]|0.516|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.515|
|[[:human genes:s:supt6h|SUPT6H]]|0.512|
|[[:human genes:c:cope|COPE]]|0.511|
|[[:human genes:c:cbwd3|CBWD3]]|0.509|
|[[:human genes:m:med17|MED17]]|0.508|
|[[:human genes:p:pan3|PAN3]]|0.502|
|[[:human genes:c:c14orf93|C14orf93]]|0.498|
|[[:human genes:c:cbwd5|CBWD5]]|0.497|
|[[:human genes:p:psmb4|PSMB4]]|0.496|
|[[:human genes:p:plk1|PLK1]]|0.493|
|[[:human genes:n:nupl1|NUPL1]]|0.492|
|[[:human genes:c:cdc45|CDC45]]|0.487|
|[[:human genes:p:pola2|POLA2]]|0.485|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.484|
|[[:human genes:p:psma6|PSMA6]]|0.483|
|[[:human genes:f:fam231c|FAM231C]]|0.482|
|[[:human genes:t:ticrr|TICRR]]|0.482|
|[[:human genes:f:fam231a|FAM231A]]|0.481|
|[[:human genes:c:chmp2a|CHMP2A]]|0.48|
|[[:human genes:c:cbwd6|CBWD6]]|0.479|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.479|
|[[:human genes:p:psmc1|PSMC1]]|0.477|
|[[:human genes:t:tceb3c|TCEB3C]]|0.477|
|[[:human genes:a:ankle2|ANKLE2]]|0.476|
|[[:human genes:c:chd4|CHD4]]|0.475|
|[[:human genes:c:ccna2|CCNA2]]|0.475|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.473|
|[[:human genes:s:snrpa1|SNRPA1]]|0.473|
|[[:human genes:v:vasn|VASN]]|0.471|
|[[:human genes:n:nup155|NUP155]]|0.47|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.47|
|[[:human genes:s:ssh2|SSH2]]|0.469|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.467|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.467|
|[[:human genes:h:hap1|HAP1]]|0.467|
|[[:human genes:s:syt9|SYT9]]|0.466|
|[[:human genes:p:pola1|POLA1]]|0.466|
|[[:human genes:d:ddtl|DDTL]]|0.465|
|[[:human genes:m:mdm2|MDM2]]|0.464|
|[[:human genes:p:psmb2|PSMB2]]|0.461|
|[[:human genes:p:pan2|PAN2]]|0.46|
|[[:human genes:p:psmb1|PSMB1]]|0.458|
|[[:human genes:t:twistnb|TWISTNB]]|0.457|
|[[:human genes:s:scaf1|SCAF1]]|0.453|
|[[:human genes:s:supt5h|SUPT5H]]|0.453|
|[[:human genes:p:polr2j3|POLR2J3]]|0.452|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.451|
|[[:human genes:k:kctd17|KCTD17]]|0.45|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.448|
|[[:human genes:p:pole|POLE]]|0.448|
|[[:human genes:z:zfand5|ZFAND5]]|0.448|
|[[:human genes:l:lrr1|LRR1]]|0.446|
|[[:human genes:i:ik|IK]]|0.443|
|[[:human genes:s:smg1|SMG1]]|0.442|
|[[:human genes:c:cwc22|CWC22]]|0.442|
|[[:human genes:u:ubl5|UBL5]]|0.442|
|[[:human genes:p:psmd11|PSMD11]]|0.441|
|[[:human genes:p:psma1|PSMA1]]|0.44|
|[[:human genes:t:traip|TRAIP]]|0.44|
|[[:human genes:d:dtl|DTL]]|0.44|
|[[:human genes:m:med15|MED15]]|0.439|
|[[:human genes:s:slc4a1|SLC4A1]]|0.439|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.439|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.439|
|[[:human genes:r:rpl35|RPL35]]|0.437|
|[[:human genes:p:pcf11|PCF11]]|0.437|
|[[:human genes:r:rrp15|RRP15]]|0.434|
|[[:human genes:p:psmc6|PSMC6]]|0.432|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.431|
|[[:human genes:n:nup160|NUP160]]|0.429|
|[[:human genes:s:stil|STIL]]|0.428|
|[[:human genes:p:paf1|PAF1]]|0.428|
|[[:human genes:c:copg1|COPG1]]|0.427|
|[[:human genes:r:rbbp5|RBBP5]]|0.427|
|[[:human genes:c:cdca3|CDCA3]]|0.426|
|[[:human genes:o:or10g3|OR10G3]]|0.426|
|[[:human genes:c:cdc73|CDC73]]|0.426|
|[[:human genes:k:krt78|KRT78]]|0.425|
|[[:human genes:s:s1pr4|S1PR4]]|0.424|
|[[:human genes:l:lad1|LAD1]]|0.424|
|[[:human genes:c:chchd3|CHCHD3]]|0.424|
|[[:human genes:o:ogfr|OGFR]]|0.424|
|[[:human genes:g:golga8j|GOLGA8J]]|0.424|
|[[:human genes:k:kpnb1|KPNB1]]|0.423|
|[[:human genes:i:igfn1|IGFN1]]|0.423|
|[[:human genes:n:npipb8|NPIPB8]]|0.422|
|[[:human genes:r:rrn3|RRN3]]|0.422|
|[[:human genes:f:fbxw9|FBXW9]]|0.421|
|[[:human genes:n:nbpf10|NBPF10]]|0.42|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.419|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.419|
|[[:human genes:a:aqr|AQR]]|0.418|
|[[:human genes:c:cdc6|CDC6]]|0.418|
|[[:human genes:d:dido1|DIDO1]]|0.417|
|[[:human genes:m:mat2a|MAT2A]]|0.417|
|[[:human genes:m:myb|MYB]]|0.417|
|[[:human genes:r:rnpc3|RNPC3]]|0.417|
|[[:human genes:n:nup205|NUP205]]|0.416|
|[[:human genes:f:fancm|FANCM]]|0.416|
|[[:human genes:d:ddx23|DDX23]]|0.415|
|[[:human genes:s:sfpq|SFPQ]]|0.415|
|[[:human genes:c:chaf1a|CHAF1A]]|0.414|
|[[:human genes:s:slc38a7|SLC38A7]]|0.413|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:r:rad51|RAD51]]|0.412|
|[[:human genes:r:rpsa|RPSA]]|0.412|
|[[:human genes:g:golga8o|GOLGA8O]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.411|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.411|
|[[:human genes:d:dock6|DOCK6]]|0.41|
|[[:human genes:r:rps12|RPS12]]|0.41|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.41|
|[[:human genes:s:sec13|SEC13]]|0.41|
|[[:human genes:s:srsf1|SRSF1]]|0.41|
|[[:human genes:r:rfxank|RFXANK]]|0.409|
|[[:human genes:o:orc1|ORC1]]|0.409|
|[[:human genes:p:psmb3|PSMB3]]|0.408|
|[[:human genes:d:dnm2|DNM2]]|0.408|
|[[:human genes:c:copb1|COPB1]]|0.408|
|[[:human genes:z:znf655|ZNF655]]|0.408|
|[[:human genes:g:gpx4|GPX4]]|0.406|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.406|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.405|
|[[:human genes:p:psmd2|PSMD2]]|0.405|
|[[:human genes:p:ppfia4|PPFIA4]]|0.405|
|[[:human genes:w:wdr43|WDR43]]|0.404|
|[[:human genes:i:iscu|ISCU]]|0.404|
|[[:human genes:p:polr2d|POLR2D]]|0.403|
|[[:human genes:s:slc6a17|SLC6A17]]|0.403|
|[[:human genes:c:copb2|COPB2]]|0.403|
|[[:human genes:c:ccdc94|CCDC94]]|0.402|
|[[:human genes:r:rps2|RPS2]]|0.402|
|[[:human genes:m:mau2|MAU2]]|0.401|
|[[:human genes:u:uqcrh|UQCRH]]|0.401|
|[[:human genes:c:copa|COPA]]|0.4|
|[[:human genes:d:ddx56|DDX56]]|0.4|
|[[:human genes:g:golga6a|GOLGA6A]]|0.4|
|[[:human genes:b:bysl|BYSL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 692/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|24/25|
|breast|28/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|20/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|14/14|
|ovary|24/26|
|pancreas|21/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD21 Expression in NALM6 Cells: 8.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>