======= RAD51B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD51B
  * **<color #00a2e8>Official Name</color>**: RAD51 paralog B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5890|5890]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15315|O15315]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD51B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD51B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KaiC|
|Rad51|
|DnaB C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rad51B-Rad51C-Rad51D-XRCC2 complex|
|four-way junction DNA binding|
|replication fork|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|DNA-dependent ATPase activity|
|reciprocal meiotic recombination|
|homologous recombination|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of cell cycle phase transition|
|double-strand break repair via homologous recombination|
|recombinational repair|
|double-stranded DNA binding|
|single-stranded DNA binding|
|meiosis I|
|meiosis I cell cycle process|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|meiotic cell cycle process|
|double-strand break repair|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|DNA recombination|
|meiotic cell cycle|
|nuclear division|
|positive regulation of cell cycle process|
|blood coagulation|
|coagulation|
|hemostasis|
|organelle fission|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|wound healing|
|regulation of body fluid levels|
|DNA repair|
|response to wounding|
|regulation of mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|ATP binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.4|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.05|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.02|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.98|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.92|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.92|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.88|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.86|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.84|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.83|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.77|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcm9|MCM9]]|0.484|
|[[:human genes:m:mad2l2|MAD2L2]]|0.438|
|[[:human genes:x:xrcc2|XRCC2]]|0.436|
|[[:human genes:r:rad51d|RAD51D]]|0.433|
|[[:human genes:s:swi5|SWI5]]|0.415|
|[[:human genes:m:mcm8|MCM8]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1328
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD51B Expression in NALM6 Cells: 3.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>