======= RAD51D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD51D
  * **<color #00a2e8>Official Name</color>**: RAD51 paralog D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5892|5892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75771|O75771]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD51D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD51D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602954|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad51|
|KaiC|
|DnaB C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|strand invasion|
|Rad51B-Rad51C-Rad51D-XRCC2 complex|
|four-way junction DNA binding|
|replication fork|
|gamma-tubulin binding|
|DNA-dependent ATPase activity|
|chromosome, telomeric region|
|reciprocal meiotic recombination|
|interstrand cross-link repair|
|homologous recombination|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|telomere organization|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|meiosis I|
|meiosis I cell cycle process|
|meiotic nuclear division|
|meiotic cell cycle process|
|double-strand break repair|
|DNA recombination|
|meiotic cell cycle|
|nuclear division|
|organelle fission|
|anatomical structure homeostasis|
|centrosome|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|ATP binding|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.61|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.29|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcm9|MCM9]]|0.457|
|[[:human genes:r:rad51b|RAD51B]]|0.433|
|[[:human genes:m:mad2l2|MAD2L2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 329/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|15/28|
|bone|15/26|
|breast|13/33|
|central nervous system|25/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|8/21|
|liver|7/20|
|lung|32/75|
|lymphocyte|6/16|
|ovary|12/26|
|pancreas|12/24|
|peripheral nervous system|3/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|15/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD51D Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>