======= RAN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAN
  * **<color #00a2e8>Official Name</color>**: RAN, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5901|5901]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62826|P62826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601179|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640). {ECO:0000269|PubMed:10400640, ECO:0000269|PubMed:10408446, ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:7819259, ECO:0000269|PubMed:8276887, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8636225, ECO:0000269|PubMed:8692944, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9428644, ECO:0000269|PubMed:9822603, ECO:0000305|PubMed:26272610}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNA import into nucleus|
|pre-miRNA export from nucleus|
|RNA nuclear export complex|
|RNA import into nucleus|
|snRNA transport|
|pre-miRNA binding|
|ribosomal small subunit export from nucleus|
|protein localization to nucleolus|
|ribosomal large subunit export from nucleus|
|nuclear export signal receptor activity|
|ribosome localization|
|ribosomal subunit export from nucleus|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|miRNA metabolic process|
|GTP metabolic process|
|Flemming body|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|androgen receptor signaling pathway|
|positive regulation of protein import into nucleus|
|ncRNA export from nucleus|
|positive regulation of protein import|
|guanosine-containing compound metabolic process|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|androgen receptor binding|
|gene silencing by miRNA|
|intracellular transport of virus|
|regulation of protein import into nucleus|
|host cell|
|regulation of cholesterol metabolic process|
|transport of virus|
|posttranscriptional gene silencing by RNA|
|regulation of protein import|
|posttranscriptional gene silencing|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|positive regulation of nucleocytoplasmic transport|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|intracellular steroid hormone receptor signaling pathway|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|GDP binding|
|positive regulation of protein localization to nucleus|
|regulation of alcohol biosynthetic process|
|ribonucleoside metabolic process|
|mitotic spindle organization|
|gene silencing by RNA|
|regulation of steroid biosynthetic process|
|nucleoside triphosphate metabolic process|
|positive regulation of protein binding|
|protein import into nucleus|
|melanosome|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of nucleocytoplasmic transport|
|mitotic sister chromatid segregation|
|nucleoside metabolic process|
|regulation of steroid metabolic process|
|import into nucleus|
|chromatin|
|recycling endosome|
|regulation of protein localization to nucleus|
|steroid hormone mediated signaling pathway|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|glycosyl compound metabolic process|
|sister chromatid segregation|
|centriole|
|protein import|
|mitotic nuclear division|
|protein export from nucleus|
|gene silencing|
|positive regulation of intracellular protein transport|
|spindle organization|
|midbody|
|nuclear export|
|protein localization to nucleus|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|positive regulation of binding|
|nuclear envelope|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|positive regulation of intracellular transport|
|magnesium ion binding|
|RNA localization|
|nuclear chromosome segregation|
|regulation of protein binding|
|regulation of intracellular protein transport|
|regulation of gene expression, epigenetic|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|chromosome segregation|
|nuclear division|
|ribosome biogenesis|
|cadherin binding|
|purine ribonucleotide metabolic process|
|organelle fission|
|positive regulation of cellular protein localization|
|ribonucleotide metabolic process|
|response to steroid hormone|
|GTPase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|regulation of intracellular transport|
|establishment of organelle localization|
|purine-containing compound metabolic process|
|regulation of binding|
|GTP binding|
|chromatin binding|
|regulation of lipid metabolic process|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|ribonucleoprotein complex biogenesis|
|positive regulation of establishment of protein localization|
|ncRNA metabolic process|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|cell division|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|microtubule-based process|
|mitotic cell cycle|
|viral process|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|symbiotic process|
|interspecies interaction between organisms|
|response to lipid|
|nucleolus|
|organophosphate metabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|positive regulation of transport|
|intracellular protein transport|
|cell cycle process|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|chromosome organization|
|cytoskeleton organization|
|cellular response to endogenous stimulus|
|cell cycle|
|RNA binding|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.75|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.8|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.88|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.95|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.565|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.444|
|[[:human genes:c:chd4|CHD4]]|0.432|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.424|
|[[:human genes:o:orc6|ORC6]]|0.419|
|[[:human genes:v:vasn|VASN]]|0.416|
|[[:human genes:m:med17|MED17]]|0.416|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.411|
|[[:human genes:a:akirin2|AKIRIN2]]|0.41|
|[[:human genes:p:psmc6|PSMC6]]|0.408|
|[[:human genes:x:xage1b|XAGE1B]]|0.404|
|[[:human genes:x:xage1e|XAGE1E]]|0.404|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:z:zfand5|ZFAND5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 31
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAN Expression in NALM6 Cells: 9.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>