======= RANBP9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RANBP9
  * **<color #00a2e8>Official Name</color>**: RAN binding protein 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10048|10048]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96S59|Q96S59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RANBP9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RANBP9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603854|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RanBPM CRA|
|LisH|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule nucleation|
|microtubule associated complex|
|microtubule polymerization|
|Ran GTPase binding|
|microtubule polymerization or depolymerization|
|negative regulation of ERK1 and ERK2 cascade|
|protein polymerization|
|ubiquitin ligase complex|
|negative regulation of MAPK cascade|
|axon guidance|
|neuron projection guidance|
|regulation of ERK1 and ERK2 cascade|
|enzyme binding|
|axonogenesis|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of phosphorylation|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|negative regulation of intracellular signal transduction|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|neuron projection development|
|microtubule-based process|
|cell morphogenesis|
|regulation of MAPK cascade|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|protein phosphorylation|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.85|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.79|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.7|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.92|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.34|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.72|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.81|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:maea|MAEA]]|0.468|
|[[:human genes:u:ube2h|UBE2H]]|0.444|
|[[:human genes:g:gid8|GID8]]|0.42|
|[[:human genes:h:hars|HARS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11743
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RANBP9 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>