======= RANGAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RANGAP1
  * **<color #00a2e8>Official Name</color>**: Ran GTPase activating protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5905|5905]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46060|P46060]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RANGAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RANGAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602362|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RanGAP1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic periphery of the nuclear pore complex|
|response to vasopressin|
|cellular response to vasopressin|
|nuclear pore cytoplasmic filaments|
|negative regulation of protein export from nucleus|
|negative regulation of nucleocytoplasmic transport|
|maintenance of protein location in nucleus|
|Ran GTPase binding|
|regulation of protein export from nucleus|
|maintenance of protein localization in organelle|
|negative regulation of intracellular protein transport|
|aggresome|
|response to axon injury|
|axon cytoplasm|
|negative regulation of intracellular transport|
|protein sumoylation|
|nuclear pore|
|maintenance of protein location in cell|
|mitotic spindle|
|kinetochore|
|condensed chromosome kinetochore|
|maintenance of location in cell|
|activation of GTPase activity|
|regulation of nucleocytoplasmic transport|
|maintenance of protein location|
|negative regulation of cellular protein localization|
|protein localization to nucleus|
|maintenance of location|
|nuclear envelope|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of intracellular protein transport|
|nuclear membrane|
|cellular response to peptide hormone stimulus|
|GTPase activator activity|
|ubiquitin protein ligase binding|
|cadherin binding|
|peptidyl-lysine modification|
|cellular response to peptide|
|regulation of intracellular transport|
|response to peptide hormone|
|positive regulation of GTPase activity|
|dendrite|
|response to peptide|
|regulation of GTPase activity|
|negative regulation of transport|
|regulation of cellular protein localization|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|RNA binding|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.98|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.72|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.72|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.74|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.8|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.83|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.84|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.84|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.91|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.94|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.16|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.18|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.3|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.36|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.39|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.512|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.45|
|[[:human genes:p:psmb2|PSMB2]]|0.45|
|[[:human genes:n:nupl1|NUPL1]]|0.442|
|[[:human genes:p:psmb4|PSMB4]]|0.434|
|[[:human genes:r:rrn3|RRN3]]|0.426|
|[[:human genes:n:nup153|NUP153]]|0.417|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:c:cdca3|CDCA3]]|0.413|
|[[:human genes:s:stil|STIL]]|0.413|
|[[:human genes:z:znf830|ZNF830]]|0.412|
|[[:human genes:s:slc6a17|SLC6A17]]|0.411|
|[[:human genes:c:cdc45|CDC45]]|0.411|
|[[:human genes:c:cnot3|CNOT3]]|0.41|
|[[:human genes:p:polr2f|POLR2F]]|0.408|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.407|
|[[:human genes:p:psmb3|PSMB3]]|0.405|
|[[:human genes:r:ranbp2|RANBP2]]|0.405|
|[[:human genes:v:vps28|VPS28]]|0.403|
|[[:human genes:p:psma6|PSMA6]]|0.401|
|[[:human genes:t:ticrr|TICRR]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 450/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|21/28|
|bone|13/26|
|breast|23/33|
|central nervous system|35/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|8/21|
|liver|11/20|
|lung|52/75|
|lymphocyte|14/16|
|ovary|15/26|
|pancreas|18/24|
|peripheral nervous system|5/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|16/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RANGAP1 Expression in NALM6 Cells: 7.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>