======= RAP1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAP1A
  * **<color #00a2e8>Official Name</color>**: RAP1A, member of RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5906|5906]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62834|P62834]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAP1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAP1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|Rap guanyl-nucleotide exchange factor activity|
|negative regulation of synaptic vesicle exocytosis|
|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|positive regulation of Fc receptor mediated stimulatory signaling pathway|
|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|
|positive regulation of vasculogenesis|
|negative regulation of collagen biosynthetic process|
|negative regulation of collagen metabolic process|
|Rap protein signal transduction|
|guanyl-nucleotide exchange factor complex|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|negative regulation of neurotransmitter secretion|
|nerve growth factor signaling pathway|
|regulation of vasculogenesis|
|regulation of receptor localization to synapse|
|microvillus assembly|
|microvillus organization|
|negative regulation of neurotransmitter transport|
|negative regulation of regulated secretory pathway|
|regulation of protein localization to synapse|
|neurotrophin signaling pathway|
|liver regeneration|
|establishment of endothelial barrier|
|negative regulation of exocytosis|
|regulation of collagen biosynthetic process|
|positive regulation of glucose import|
|regulation of collagen metabolic process|
|positive regulation of glucose transmembrane transport|
|cellular response to nerve growth factor stimulus|
|endothelial cell development|
|response to nerve growth factor|
|cellular response to cAMP|
|regulation of glucose import|
|phagocytic vesicle|
|negative regulation of synaptic transmission|
|positive regulation of phagocytosis|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|regulation of glucose transmembrane transport|
|animal organ regeneration|
|GDP binding|
|regulation of synaptic vesicle exocytosis|
|cellular response to carbohydrate stimulus|
|endothelial cell differentiation|
|cellular glucose homeostasis|
|regulation of cell junction assembly|
|specific granule membrane|
|response to antineoplastic agent|
|endothelium development|
|regulation of phagocytosis|
|response to cAMP|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of protein localization to cell periphery|
|liver development|
|late endosome|
|hepaticobiliary system development|
|response to organophosphorus|
|response to glucose|
|regulation of neurotransmitter transport|
|response to hexose|
|response to monosaccharide|
|response to purine-containing compound|
|regeneration|
|regulation of regulated secretory pathway|
|response to carbohydrate|
|regulation of insulin secretion|
|positive regulation of vasculature development|
|protein localization to plasma membrane|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of protein localization to membrane|
|epithelial cell development|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of immune effector process|
|regulation of exocytosis|
|protein localization to cell periphery|
|negative regulation of secretion|
|Ras protein signal transduction|
|early endosome|
|protein-containing complex binding|
|regulation of hormone secretion|
|positive regulation of neuron projection development|
|regulation of ERK1 and ERK2 cascade|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|neuron projection|
|GTPase activity|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|GTP binding|
|cellular response to drug|
|gland development|
|positive regulation of GTPase activity|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|protein localization to membrane|
|regulation of GTPase activity|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|positive regulation of immune response|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.18|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.12|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.98|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.88|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.85|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10343
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAP1A Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>