======= RAP1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAP1B
  * **<color #00a2e8>Official Name</color>**: RAP1B, member of RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5908|5908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61224|P61224]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAP1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAP1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|GTP EFTU|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of synaptic vesicle exocytosis|
|cellular response to gonadotropin-releasing hormone|
|negative regulation of calcium ion-dependent exocytosis|
|response to gonadotropin-releasing hormone|
|Rap protein signal transduction|
|negative regulation of neurotransmitter secretion|
|microvillus assembly|
|microvillus organization|
|regulation of establishment of cell polarity|
|negative regulation of neurotransmitter transport|
|regulation of establishment or maintenance of cell polarity|
|negative regulation of regulated secretory pathway|
|establishment of endothelial barrier|
|negative regulation of exocytosis|
|regulation of calcium ion-dependent exocytosis|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|endothelial cell development|
|cellular response to cAMP|
|azurophil granule membrane|
|negative regulation of synaptic transmission|
|GDP binding|
|regulation of synaptic vesicle exocytosis|
|lipid droplet|
|endothelial cell differentiation|
|intracellular|
|regulation of cell junction assembly|
|endothelium development|
|response to cAMP|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|response to organophosphorus|
|regulation of neurotransmitter transport|
|response to purine-containing compound|
|regulation of regulated secretory pathway|
|cell-cell junction|
|response to carbohydrate|
|epithelial cell development|
|negative regulation of secretion by cell|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of exocytosis|
|membrane raft|
|negative regulation of secretion|
|Ras protein signal transduction|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|regulation of ERK1 and ERK2 cascade|
|small GTPase mediated signal transduction|
|cellular response to peptide|
|GTPase activity|
|regulation of neurotransmitter levels|
|GTP binding|
|response to peptide hormone|
|cellular response to drug|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|response to peptide|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|regulated exocytosis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|leukocyte activation|
|regulation of cellular component biogenesis|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|epithelium development|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.7|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.73|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.92|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAP1B Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>