======= RAPGEF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAPGEF1
  * **<color #00a2e8>Official Name</color>**: Rap guanine nucleotide exchange factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2889|2889]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13905|Q13905]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAPGEF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAPGEF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGEF N|
|RasGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|Rap guanyl-nucleotide exchange factor activity|
|positive regulation of Fc receptor mediated stimulatory signaling pathway|
|regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|
|Rap protein signal transduction|
|nerve growth factor signaling pathway|
|regulation of Fc receptor mediated stimulatory signaling pathway|
|negative regulation of neural precursor cell proliferation|
|neurotrophin signaling pathway|
|establishment of endothelial barrier|
|platelet-derived growth factor receptor signaling pathway|
|negative regulation of protein kinase B signaling|
|cellular response to nerve growth factor stimulus|
|endothelial cell development|
|response to nerve growth factor|
|negative regulation of Ras protein signal transduction|
|activation of MAPKK activity|
|cellular response to cAMP|
|negative regulation of small GTPase mediated signal transduction|
|positive regulation of Ras protein signal transduction|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of phagocytosis|
|positive regulation of small GTPase mediated signal transduction|
|phagocytic vesicle membrane|
|endothelial cell differentiation|
|regulation of neural precursor cell proliferation|
|regulation of cell junction assembly|
|regulation of phagocytosis|
|endothelium development|
|activation of GTPase activity|
|response to cAMP|
|guanyl-nucleotide exchange factor activity|
|SH3 domain binding|
|response to organophosphorus|
|response to purine-containing compound|
|negative regulation of MAPK cascade|
|negative regulation of canonical Wnt signaling pathway|
|regulation of JNK cascade|
|epithelial cell development|
|negative regulation of Wnt signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|early endosome|
|positive regulation of MAP kinase activity|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|regulation of ERK1 and ERK2 cascade|
|small GTPase mediated signal transduction|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|negative regulation of phosphorylation|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|blood vessel development|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAPGEF1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>