======= RAPSN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAPSN
  * **<color #00a2e8>Official Name</color>**: receptor associated protein of the synapse
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5913|5913]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13702|Q13702]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAPSN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAPSN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601592|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rapsyn N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of neuromuscular synaptic transmission|
|positive regulation of neuromuscular synaptic transmission|
|postsynaptic specialization membrane|
|regulation of postsynaptic membrane organization|
|acetylcholine receptor binding|
|protein membrane anchor|
|establishment of protein localization to postsynaptic membrane|
|synaptic transmission, cholinergic|
|ionotropic glutamate receptor binding|
|protein localization to postsynaptic membrane|
|positive regulation of neuron apoptotic process|
|protein localization to synapse|
|neuromuscular junction|
|positive regulation of neuron death|
|regulation of postsynapse organization|
|positive regulation of synaptic transmission|
|regulation of neuron apoptotic process|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|establishment of protein localization to membrane|
|regulation of neuron death|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|centrosome|
|cell junction|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|Golgi apparatus|
|cell-cell signaling|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.48|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.05|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.92|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.81|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.9|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.92|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.98|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.38|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3130
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAPSN Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>