======= RARB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RARB
  * **<color #00a2e8>Official Name</color>**: retinoic acid receptor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5915|5915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10826|P10826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RARB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RARB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. {ECO:0000269|PubMed:12554770}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinoic acid receptor signaling pathway|
|ventricular cardiac muscle cell differentiation|
|retinoid X receptor binding|
|striatum development|
|glandular epithelial cell development|
|negative regulation of chondrocyte differentiation|
|subpallium development|
|outflow tract septum morphogenesis|
|embryonic hindlimb morphogenesis|
|negative regulation of cartilage development|
|embryonic digestive tract development|
|embryonic eye morphogenesis|
|growth plate cartilage development|
|hindlimb morphogenesis|
|glandular epithelial cell differentiation|
|regulation of myelination|
|endochondral bone growth|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|nuclear receptor activity|
|columnar/cuboidal epithelial cell development|
|regulation of chondrocyte differentiation|
|steroid hormone receptor activity|
|drug binding|
|nuclear receptor transcription coactivator activity|
|cellular response to retinoic acid|
|regulation of cartilage development|
|RNA polymerase II transcription factor complex|
|endochondral bone morphogenesis|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|transcription regulatory region sequence-specific DNA binding|
|multicellular organism growth|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|cardiac muscle cell differentiation|
|mesonephros development|
|columnar/cuboidal epithelial cell differentiation|
|organ growth|
|response to retinoic acid|
|cardiac septum development|
|bone morphogenesis|
|cardiocyte differentiation|
|steroid hormone mediated signaling pathway|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|liver development|
|cardiac chamber morphogenesis|
|kidney epithelium development|
|hepaticobiliary system development|
|digestive tract development|
|digestive system development|
|eye morphogenesis|
|appendage morphogenesis|
|limb morphogenesis|
|cardiac muscle tissue development|
|intracellular receptor signaling pathway|
|cardiac chamber development|
|hormone-mediated signaling pathway|
|cartilage development|
|transcription initiation from RNA polymerase II promoter|
|appendage development|
|limb development|
|cellular response to steroid hormone stimulus|
|epithelial cell development|
|bone development|
|striated muscle cell differentiation|
|signaling receptor activity|
|cellular response to acid chemical|
|DNA-templated transcription, initiation|
|connective tissue development|
|skeletal system morphogenesis|
|muscle cell differentiation|
|heart morphogenesis|
|sensory organ morphogenesis|
|telencephalon development|
|protein-containing complex binding|
|kidney development|
|renal system development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle tissue development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|response to steroid hormone|
|transcription factor binding|
|response to acid chemical|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of neuron differentiation|
|forebrain development|
|developmental growth|
|growth|
|gland development|
|embryonic organ development|
|positive regulation of neurogenesis|
|muscle structure development|
|transcription by RNA polymerase II|
|skeletal system development|
|cellular response to lipid|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|sensory organ development|
|embryonic morphogenesis|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|zinc ion binding|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|cellular response to oxygen-containing compound|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16947
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RARB Expression in NALM6 Cells: 0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>