======= RASAL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RASAL3
  * **<color #00a2e8>Official Name</color>**: RAS protein activator like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64926|64926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YV0|Q86YV0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RASAL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RASAL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616561|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of membrane|
|positive regulation of NK T cell proliferation|
|regulation of NK T cell proliferation|
|positive regulation of NK T cell activation|
|regulation of NK T cell activation|
|positive regulation of alpha-beta T cell proliferation|
|regulation of alpha-beta T cell proliferation|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|cell cortex|
|positive regulation of leukocyte proliferation|
|regulation of T cell proliferation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|GTPase activator activity|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of cell adhesion|
|positive regulation of hydrolase activity|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.97|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6550
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RASAL3 Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>