======= RB1CC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RB1CC1
  * **<color #00a2e8>Official Name</color>**: RB1 inducible coiled-coil 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9821|9821]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDY2|Q8TDY2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RB1CC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RB1CC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATG11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycophagy|
|lysosomal microautophagy|
|piecemeal microautophagy of the nucleus|
|reticulophagy|
|autophagy of nucleus|
|autophagy of peroxisome|
|Atg1/ULK1 kinase complex|
|positive regulation of cell size|
|phagophore assembly site membrane|
|glycogen catabolic process|
|glucan catabolic process|
|cellular polysaccharide catabolic process|
|selective autophagy|
|polysaccharide catabolic process|
|phagophore assembly site|
|cellular carbohydrate catabolic process|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|autophagosome assembly|
|energy reserve metabolic process|
|organelle disassembly|
|autophagosome organization|
|extrinsic component of membrane|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|negative regulation of extrinsic apoptotic signaling pathway|
|carbohydrate catabolic process|
|liver development|
|hepaticobiliary system development|
|vacuole organization|
|positive regulation of JNK cascade|
|regulation of extrinsic apoptotic signaling pathway|
|macroautophagy|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|cellular carbohydrate metabolic process|
|regulation of macroautophagy|
|regulation of cell size|
|regulation of JNK cascade|
|negative regulation of apoptotic signaling pathway|
|regulation of stress-activated MAPK cascade|
|energy derivation by oxidation of organic compounds|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear membrane|
|lysosome|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of autophagy|
|regulation of cellular component size|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|gland development|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|protein kinase binding|
|carbohydrate metabolic process|
|regulation of anatomical structure size|
|heart development|
|positive regulation of MAPK cascade|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of cellular catabolic process|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|regulation of catabolic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.79|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.31|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.89|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.86|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.81|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.73|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.82|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.464|
|[[:human genes:w:wipi2|WIPI2]]|0.444|
|[[:human genes:c:c12orf44|C12orf44]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RB1CC1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>