======= RBM15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM15
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64783|64783]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96T37|Q96T37]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606077|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|SPOC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thrombopoietin-mediated signaling pathway|
|RNA N6-methyladenosine methyltransferase complex|
|dosage compensation by inactivation of X chromosome|
|positive regulation of transcription of Notch receptor target|
|dosage compensation|
|branching involved in blood vessel morphogenesis|
|placenta blood vessel development|
|spleen development|
|ventricular septum morphogenesis|
|regulation of megakaryocyte differentiation|
|regulation of alternative mRNA splicing, via spliceosome|
|ventricular septum development|
|cardiac septum morphogenesis|
|negative regulation of myeloid cell differentiation|
|chemokine-mediated signaling pathway|
|RNA methylation|
|cellular response to chemokine|
|response to chemokine|
|regulation of mRNA splicing, via spliceosome|
|cardiac septum development|
|Notch signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|branching morphogenesis of an epithelial tube|
|regulation of RNA splicing|
|negative regulation of hemopoiesis|
|regulation of mRNA processing|
|placenta development|
|morphogenesis of a branching epithelium|
|mRNA binding|
|RNA modification|
|morphogenesis of a branching structure|
|cardiac chamber development|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|nuclear membrane|
|heart morphogenesis|
|macromolecule methylation|
|epithelial tube morphogenesis|
|methylation|
|angiogenesis|
|regulation of mRNA metabolic process|
|nuclear speck|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|viral process|
|negative regulation of cell differentiation|
|symbiotic process|
|interspecies interaction between organisms|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cellular response to cytokine stimulus|
|response to cytokine|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.9|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.59|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.52|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.46|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.34|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.33|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.28|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.06|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.97|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.93|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.9|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.89|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.84|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.76|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.74|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.72|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.74|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.8|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.94|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.12|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.15|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kpna4|KPNA4]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17904
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM15 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>