======= RBM4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM4
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5936|5936]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BWF3|Q9BWF3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602571|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2- containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCHC|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-mRNA intronic pyrimidine-rich binding|
|IRES-dependent translational initiation of linear mRNA|
|cap-independent translational initiation|
|cap-independent translational initiation of linear mRNA|
|circadian regulation of translation|
|negative regulation of translation in response to stress|
|pre-mRNA intronic binding|
|miRNA mediated inhibition of translation|
|negative regulation of translation, ncRNA-mediated|
|regulation of translation, ncRNA-mediated|
|regulation of translation in response to stress|
|negative regulation of translational initiation|
|entrainment of circadian clock by photoperiod|
|photoperiodism|
|entrainment of circadian clock|
|cytoplasmic translational initiation|
|cyclin binding|
|miRNA binding|
|response to arsenic-containing substance|
|mRNA cis splicing, via spliceosome|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|regulation of alternative mRNA splicing, via spliceosome|
|cytoplasmic stress granule|
|cytoplasmic translation|
|mRNA 3-UTR binding|
|regulation of translational initiation|
|positive regulation of muscle cell differentiation|
|gene silencing by RNA|
|regulation of mRNA splicing, via spliceosome|
|regulation of nucleocytoplasmic transport|
|regulation of circadian rhythm|
|negative regulation of translation|
|regulation of RNA splicing|
|regulation of mRNA processing|
|circadian rhythm|
|translational initiation|
|negative regulation of cellular amide metabolic process|
|gene silencing|
|regulation of muscle cell differentiation|
|mRNA binding|
|regulation of gene expression, epigenetic|
|rhythmic process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|response to light stimulus|
|regulation of mRNA metabolic process|
|regulation of intracellular transport|
|regulation of translation|
|translation|
|RNA splicing|
|nuclear speck|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|response to radiation|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|cellular amide metabolic process|
|zinc ion binding|
|nucleolus|
|RNA processing|
|regulation of cellular localization|
|positive regulation of cell differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.81|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.85|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.86|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.92|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM4 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>