======= RC3H2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RC3H2
  * **<color #00a2e8>Official Name</color>**: ring finger and CCCH-type domains 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54542|54542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBD1|Q9HBD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RC3H2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RC3H2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T follicular helper cell differentiation|
|negative regulation of T-helper 17 cell differentiation|
|regulation of miRNA metabolic process|
|negative regulation of T-helper 17 type immune response|
|negative regulation of T-helper cell differentiation|
|regulation of T-helper 17 cell differentiation|
|lymph node development|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of T-helper 17 type immune response|
|RNA stem-loop binding|
|negative regulation of alpha-beta T cell differentiation|
|B cell homeostasis|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|T cell differentiation involved in immune response|
|spleen development|
|T cell homeostasis|
|CD4-positive, alpha-beta T cell differentiation|
|regulation of T-helper cell differentiation|
|T cell proliferation|
|negative regulation of alpha-beta T cell activation|
|CD4-positive, alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|lung alveolus development|
|negative regulation of T cell differentiation|
|negative regulation of adaptive immune response|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|alpha-beta T cell differentiation|
|lymphocyte homeostasis|
|negative regulation of lymphocyte differentiation|
|regulation of CD4-positive, alpha-beta T cell activation|
|alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|T cell activation involved in immune response|
|leukocyte homeostasis|
|double-stranded RNA binding|
|positive regulation of NIK/NF-kappaB signaling|
|multicellular organism growth|
|lymphocyte proliferation|
|P-body|
|mononuclear cell proliferation|
|post-embryonic development|
|regulation of alpha-beta T cell activation|
|leukocyte proliferation|
|negative regulation of leukocyte differentiation|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of T cell activation|
|lymphocyte activation involved in immune response|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|T cell differentiation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of adaptive immune response|
|mRNA binding|
|regulation of lymphocyte differentiation|
|lung development|
|respiratory tube development|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|T cell receptor signaling pathway|
|limb development|
|appendage development|
|respiratory system development|
|negative regulation of cell activation|
|homeostasis of number of cells|
|T cell activation|
|lymphocyte differentiation|
|ubiquitin-protein transferase activity|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|protein polyubiquitination|
|regulation of T cell activation|
|leukocyte differentiation|
|lymphocyte activation|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of immune effector process|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|posttranscriptional regulation of gene expression|
|cell population proliferation|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|protein ubiquitination|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|tube development|
|positive regulation of immune response|
|leukocyte activation|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|positive regulation of intracellular signal transduction|
|cell activation|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|RNA binding|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.75|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RC3H2 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>