======= RDX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RDX
  * **<color #00a2e8>Official Name</color>**: radixin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5962|5962]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35241|P35241]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RDX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RDX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM M|
|FERM N|
|ERM|
|FERM C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Rap protein signal transduction|
|cell tip|
|positive regulation of early endosome to late endosome transport|
|regulation of protein localization to early endosome|
|positive regulation of protein localization to early endosome|
|negative regulation of cell size|
|positive regulation of protein localization to endosome|
|apical protein localization|
|regulation of protein localization to endosome|
|positive regulation of cytoplasmic transport|
|protein kinase A signaling|
|negative regulation of homotypic cell-cell adhesion|
|barbed-end actin filament capping|
|cellular response to thyroid hormone stimulus|
|regulation of early endosome to late endosome transport|
|microvillus assembly|
|microvillus organization|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|negative regulation of adherens junction organization|
|regulation of cytoplasmic transport|
|regulation of homotypic cell-cell adhesion|
|protein kinase A binding|
|response to thyroid hormone|
|regulation of ruffle assembly|
|establishment of endothelial barrier|
|actin filament capping|
|stereocilium|
|positive regulation of G1/S transition of mitotic cell cycle|
|negative regulation of actin filament depolymerization|
|cell periphery|
|T-tubule|
|negative regulation of GTPase activity|
|positive regulation of cell cycle G1/S phase transition|
|endothelial cell development|
|regulation of actin filament depolymerization|
|cortical actin cytoskeleton|
|negative regulation of actin filament polymerization|
|cleavage furrow|
|negative regulation of protein depolymerization|
|microvillus|
|negative regulation of protein polymerization|
|regulation of adherens junction organization|
|negative regulation of protein complex disassembly|
|filopodium|
|positive regulation of mitotic cell cycle phase transition|
|ATPase binding|
|endothelial cell differentiation|
|regulation of protein depolymerization|
|ruffle|
|regulation of actin filament bundle assembly|
|positive regulation of cell cycle phase transition|
|endothelium development|
|cell-cell adherens junction|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of cytoskeleton organization|
|positive regulation of cellular protein catabolic process|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell shape|
|midbody|
|regulation of cell cycle G1/S phase transition|
|regulation of actin filament polymerization|
|negative regulation of cell-cell adhesion|
|lamellipodium|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|protein localization to plasma membrane|
|epithelial cell development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of intracellular transport|
|positive regulation of protein catabolic process|
|regulation of organelle assembly|
|regulation of protein polymerization|
|protein localization to cell periphery|
|regulation of Ras protein signal transduction|
|protein domain specific binding|
|regulation of cellular protein catabolic process|
|regulation of actin filament organization|
|actin binding|
|negative regulation of cell adhesion|
|positive regulation of cell cycle process|
|cadherin binding|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|regulation of cellular component size|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|regulation of mitotic cell cycle phase transition|
|focal adhesion|
|positive regulation of catabolic process|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|cell projection assembly|
|protein localization to membrane|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|epithelial cell differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|regulation of cell migration|
|protein homodimerization activity|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of cellular component movement|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|RNA binding|
|response to endogenous stimulus|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.32|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.75|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.07|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17387
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RDX Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>