======= RERG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RERG
  * **<color #00a2e8>Official Name</color>**: RAS like estrogen regulated growth inhibitor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85004|85004]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A58|Q96A58]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RERG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RERG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612664|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269|PubMed:11533059}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|estrogen receptor binding|
|GDP binding|
|negative regulation of cell growth|
|negative regulation of growth|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|GTPase activity|
|GTP binding|
|regulation of cell growth|
|regulation of growth|
|negative regulation of cell population proliferation|
|response to hormone|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.93|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.81|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.73|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.76|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.8|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.82|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.84|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.87|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.87|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RERG Expression in NALM6 Cells: 1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>