======= REST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REST
  * **<color #00a2e8>Official Name</color>**: RE1 silencing transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5978|5978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13127|Q13127]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600571|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of amniotic stem cell differentiation|
|negative regulation of amniotic stem cell differentiation|
|negative regulation of dense core granule biogenesis|
|negative regulation of mesenchymal stem cell differentiation|
|regulation of dense core granule biogenesis|
|negative regulation of aldosterone metabolic process|
|negative regulation of cortisol biosynthetic process|
|negative regulation of aldosterone biosynthetic process|
|negative regulation of glucocorticoid biosynthetic process|
|negative regulation of glucocorticoid metabolic process|
|positive regulation of oxidative stress-induced neuron death|
|negative regulation of steroid hormone biosynthetic process|
|regulation of mesenchymal stem cell differentiation|
|regulation of cortisol biosynthetic process|
|regulation of aldosterone metabolic process|
|regulation of aldosterone biosynthetic process|
|regulation of glucocorticoid biosynthetic process|
|negative regulation of calcium ion-dependent exocytosis|
|positive regulation of stem cell population maintenance|
|regulation of glucocorticoid metabolic process|
|negative regulation of hormone biosynthetic process|
|regulation of steroid hormone biosynthetic process|
|cardiac muscle cell myoblast differentiation|
|histone H4 deacetylation|
|negative regulation of hormone metabolic process|
|cellular response to electrical stimulus|
|negative regulation of alcohol biosynthetic process|
|cardioblast differentiation|
|negative regulation by host of viral transcription|
|modification of synaptic structure|
|positive regulation of oxidative stress-induced cell death|
|regulation of ketone biosynthetic process|
|positive regulation of cellular response to oxidative stress|
|positive regulation of response to oxidative stress|
|negative regulation of oxidative stress-induced neuron death|
|negative regulation of stem cell differentiation|
|neuronal stem cell population maintenance|
|negative regulation of steroid biosynthetic process|
|negative regulation of regulated secretory pathway|
|negative regulation of steroid metabolic process|
|regulation of oxidative stress-induced neuron death|
|negative regulation of viral transcription|
|regulation of hormone biosynthetic process|
|regulation of stem cell population maintenance|
|negative regulation of exocytosis|
|RNA polymerase II core promoter sequence-specific DNA binding|
|myoblast differentiation|
|negative regulation of insulin secretion|
|regulation of hormone metabolic process|
|histone methyltransferase complex|
|response to electrical stimulus|
|regulation of calcium ion-dependent exocytosis|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of peptide hormone secretion|
|negative regulation of response to oxidative stress|
|negative regulation of lipid biosynthetic process|
|histone deacetylation|
|response to ischemia|
|protein deacetylation|
|cellular response to glucocorticoid stimulus|
|transcriptional repressor complex|
|cellular response to corticosteroid stimulus|
|protein deacylation|
|macromolecule deacylation|
|negative regulation of hormone secretion|
|regulation of oxidative stress-induced cell death|
|regulation of viral transcription|
|somatic stem cell population maintenance|
|regulation of alternative mRNA splicing, via spliceosome|
|modification by host of symbiont morphology or physiology|
|regulation of cellular response to oxidative stress|
|regulation of alcohol biosynthetic process|
|interaction with symbiont|
|negative regulation of lipid metabolic process|
|regulation of response to oxidative stress|
|hematopoietic progenitor cell differentiation|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|positive regulation of neuron death|
|negative regulation of viral process|
|regulation of mRNA splicing, via spliceosome|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of osteoblast differentiation|
|regulation of steroid metabolic process|
|cardiocyte differentiation|
|regulation of stem cell differentiation|
|negative regulation of protein secretion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|stem cell population maintenance|
|regulation of RNA splicing|
|maintenance of cell number|
|regulation of mRNA processing|
|negative regulation of peptide secretion|
|response to glucocorticoid|
|positive regulation of cysteine-type endopeptidase activity|
|modification of morphology or physiology of other organism|
|stem cell differentiation|
|response to corticosteroid|
|regulation of regulated secretory pathway|
|regulation of cellular ketone metabolic process|
|positive regulation of endopeptidase activity|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|regulation of ossification|
|positive regulation of peptidase activity|
|negative regulation of secretion by cell|
|regulation of viral process|
|negative regulation of neuron death|
|regulation of peptide hormone secretion|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transcription regulatory region DNA binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of exocytosis|
|negative regulation of neuron differentiation|
|negative regulation of secretion|
|regulation of cysteine-type endopeptidase activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of hormone secretion|
|synapse organization|
|negative regulation of neurogenesis|
|regulation of neuron death|
|negative regulation of nervous system development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|transcription factor binding|
|negative regulation of cell development|
|response to hypoxia|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|histone modification|
|positive regulation of neuron differentiation|
|covalent chromatin modification|
|response to oxygen levels|
|chromatin binding|
|regulation of lipid metabolic process|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of small molecule metabolic process|
|regulation of peptidase activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|muscle structure development|
|negative regulation of transport|
|regulation of peptide secretion|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|heart development|
|regulation of hormone levels|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|chromatin organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|response to drug|
|regulation of protein localization|
|chromosome organization|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.48|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.35|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.17|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.12|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.09|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.03|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.96|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.95|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.79|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.78|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.76|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.75|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.73|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.71|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11012
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REST Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>