======= RETSAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RETSAT
  * **<color #00a2e8>Official Name</color>**: retinol saturase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54884|54884]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NUM9|Q6NUM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RETSAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RETSAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617597|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the saturation of all-trans-retinol to all- trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. {ECO:0000250|UniProtKB:Q64FW2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAO|
|FAD oxidored|
|Amino oxidase|
|FAD binding 2|
|Thi4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|all-trans-retinol 13,14-reductase activity|
|nuclear outer membrane|
|retinol metabolic process|
|primary alcohol metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|oxidoreductase activity|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|isoprenoid metabolic process|
|hormone metabolic process|
|nuclear membrane|
|alcohol metabolic process|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|lipid metabolic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.68|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.95|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.16|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3469
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RETSAT Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>